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8/12/2025 8:18:23 AM | Browse: 24 | Download: 129
Publication Name World Journal of Experimental Medicine
Manuscript ID 105973
Country India
Received
2025-02-12 07:00
Peer-Review Started
2025-02-13 05:42
To Make the First Decision
Return for Revision
2025-04-03 04:06
Revised
2025-04-07 18:30
Second Decision
2025-05-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-05-18 13:03
Articles in Press
2025-05-18 13:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-04 00:20
Publish the Manuscript Online
2025-08-12 08:18
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Randomized Controlled Trial
Article Title Comparative outcome analyses of stromal vascular fraction vs nanofat in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol
Manuscript Source Invited Manuscript
All Author List Naveen Jeyaraman, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Arulkumar Nallakumarasamy, Swaminathan Ramasubramanian, Sathish Muthu and Madhan Jeyaraman
ORCID
Author(s) ORCID Number
Naveen Jeyaraman http://orcid.org/0000-0002-4362-3326
Ravi Velamoor Rangarajan http://orcid.org/0009-0006-7303-8474
Arulkumar Nallakumarasamy http://orcid.org/0000-0002-2445-2883
Swaminathan Ramasubramanian http://orcid.org/0000-0001-8845-8427
Sathish Muthu http://orcid.org/0000-0002-7143-4354
Madhan Jeyaraman http://orcid.org/0000-0002-9045-9493
Funding Agency and Grant Number
Corresponding Author Madhan Jeyaraman, Assistant Professor, PhD, Postdoctoral Fellow, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words Osteoarthritis; Stromal vascular fraction; Nanofat; Regenerative therapy; Cartilage regeneration; Randomized controlled trial
Core Tip The double-blinded, randomized controlled trial at Mother Cell Regenerative Centre, Trichy, compares the efficacy and safety of stromal vascular fraction (SVF) vs nanofat in treating primary knee osteoarthritis. Over 18 months, 30 patients will receive either autologous SVF or nanofat injections. Primary outcome is pain reduction at 12 months, while secondary outcomes include functional improvement, cartilage regeneration, and monitoring adverse events. This study aims to provide clinical evidence for these regenerative therapies.
Publish Date 2025-08-12 08:18
Citation <p>Jeyaraman N, Shrivastava S, Rangarajan RV, Nallakumarasamy A, Ramasubramanian S, Muthu S, Jeyaraman M. Comparative outcome analyses of stromal vascular fraction vs nanofat in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol. <i>World J Exp Med</i> 2025; 15(3): 105973</p>
URL https://www.wjgnet.com/2220-315X/full/v15/i3/105973.htm
DOI https://dx.doi.org/10.5493/wjem.v15.i3.105973
Full Article (PDF) WJEM-15-105973-with-cover.pdf
CONSORT 2010 Statement 105973-CONSORT-2010-statement.pdf
Manuscript File 105973_Auto_Edited_064627.docx
Answering Reviewers 105973-answering-reviewers.pdf
Audio Core Tip 105973-audio.mp3
Biostatistics Review Certificate 105973-biostatistics-statement.pdf
Clinical Trial Registration Statement 105973-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 105973-conflict-of-interest-statement.pdf
Copyright License Agreement 105973-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 105973-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 105973-institutional-review-board-statement.pdf
Peer-review Report 105973-peer-reviews.pdf
Scientific Misconduct Check 105973-scientific-misconduct-check.png
Scientific Editor Work List 105973-scientific-editor-work-list.pdf
CrossCheck Report 105973-crosscheck-report.pdf