| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sebastian Mas-Fontao, Esther Civantos, Nisa Boukichou-Abdelkader, Juan Antonio Moreno, Carmen Gomez-Guerrero, M Isabel López Gálvez, Jaakko Tuomilehto, Marcus Lind, Rafael Gabriel and Jesús Egido |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III (ISCIII) Through the Project Co-Funded by the European Union |
No. PI20-00487 |
| Instituto de Salud Carlos III (ISCIII) Through the Project Co-Funded by the European Union |
No. PI23-00119 |
| Instituto de Salud Carlos III (ISCIII) Through the Project Co-Funded by the European Union |
No. PI24-01630 |
|
| Corresponding Author |
Sebastian Mas-Fontao, Renal, Vascular and Diabetes and Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM), Av Reyes Católicos 2, Madrid 28040, Spain. smas@quironsalud.es |
| Key Words |
Biomarkers; Microvascular complications; Intermediate hyperglycemia; Renal function; Tumor necrosis factor receptor |
| Core Tip |
This study identifies tumor necrosis factor (TNF) receptor superfamily members as potential early biomarkers of renal and retinal dysfunction in individuals with intermediate hyperglycemia (IH). TNF receptor 1, TNF receptor 2, and T-cell immunoglobulin and mucin domain 3 (TIM-3) are significantly associated with early-stage renal impairment, while TIM-3 shows strong predictive value for retinopathy. These findings highlight the role of inflammation in microvascular complications and suggest that integrating these biomarkers into clinical screening may improve early detection and personalized intervention strategies in IH. |
| Publish Date |
2025-09-11 09:41 |
| Citation |
<p>Mas-Fontao S, Civantos E, Boukichou-Abdelkader N, Moreno JA, Gomez-Guerrero C, Gálvez MIL, Tuomilehto J, Lind M, Gabriel R, Egido J. Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia. <i>World J Diabetes</i> 2025; 16(9): 106002</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i9/106002.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i9.106002 |
