Publication Name	World Journal of Experimental Medicine
Manuscript ID	106020
Country	India

Received	2025-02-14 09:45
Peer-Review Started	2025-02-17 01:10
To Make the First Decision
Return for Revision	2025-04-08 05:48
Revised	2025-04-09 11:19
Second Decision	2025-05-16 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-18 13:16
Articles in Press	2025-05-18 13:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-04 00:19
Publish the Manuscript Online	2025-08-12 08:18

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Randomized Controlled Trial
Article Title	Comparative outcome analyses of subchondral vs intra-articular bone marrow aspirate concentrate in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol
Manuscript Source	Invited Manuscript
All Author List	Arulkumar Nallakumarasamy, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Naveen Jeyaraman, Swaminathan Ramasubramanian, Sathish Muthu and Madhan Jeyaraman
ORCID	Author(s) ORCID Number Arulkumar Nallakumarasamy http://orcid.org/0000-0002-2445-2883 Ravi Velamoor Rangarajan http://orcid.org/0009-0006-7303-8474 Naveen Jeyaraman http://orcid.org/0000-0002-4362-3326 Swaminathan Ramasubramanian http://orcid.org/0000-0001-8845-8427 Sathish Muthu http://orcid.org/0000-0002-7143-4354 Madhan Jeyaraman http://orcid.org/0000-0002-9045-9493
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Osteoarthritis; Bone marrow aspirate concentrate; Subchondral injection; Intra-articular injection; Regenerative therapy; Randomized controlled trial
Core Tip	In this double-blinded, randomized controlled trial, 30 patients with primary knee osteoarthritis (OA) will receive either subchondral or intra-articular Bone marrow aspirate concentrate (BMAC) injections. The study aims to compare pain relief (measured by Visual Analog Scale) at 12 months. Secondary outcomes include functional improvement (Knee Injury and Osteoarthritis Outcome Score, International Knee Documentation Committee, and Western Ontario and McMaster Universities Arthritis Index scores), structural changes [magnetic resonance imaging (MRI) using the whole-organ MRI Score], and safety (adverse events). BMAC is harvested from the posterior iliac crest, processed, and administered under image guidance.
Publish Date	2025-08-12 08:18
Citation	<p>Nallakumarasamy A, Shrivastava S, Rangarajan RV, Jeyaraman N, Ramasubramanian S, Muthu S, Jeyaraman M. Comparative outcome analyses of subchondral vs intra-articular bone marrow aspirate concentrate in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol. <i>World J Exp Med</i> 2025; 15(3): 106020</p>
URL	https://www.wjgnet.com/2220-315X/full/v15/i3/106020.htm
DOI	https://dx.doi.org/10.5493/wjem.v15.i3.106020

Full Article (PDF)	WJEM-15-106020-with-cover.pdf
CONSORT 2010 Statement	106020-CONSORT-2010-statement.pdf
Manuscript File	106020-institutional-review-board-statement.pdf
Answering Reviewers	106020-answering-reviewers.pdf
Audio Core Tip	106020-audio.opus
Biostatistics Review Certificate	106020-biostatistics-statement.pdf
Clinical Trial Registration Statement	106020-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	106020-conflict-of-interest-statement.pdf
Copyright License Agreement	106020-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	106020-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	106020-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106020-non-native-speakers.pdf
Peer-review Report	106020-peer-reviews.pdf
Scientific Misconduct Check	106020-scientific-misconduct-check.png
Scientific Editor Work List	106020-scientific-editor-work-list.pdf
CrossCheck Report	106020-crosscheck-report.pdf