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6/13/2025 1:39:33 PM | Browse: 3 | Download: 0
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Received |
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2025-02-17 08:49 |
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Peer-Review Started |
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2025-02-17 08:49 |
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To Make the First Decision |
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Return for Revision |
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2025-03-11 07:17 |
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Revised |
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2025-04-01 03:55 |
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Second Decision |
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2025-04-18 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-18 07:26 |
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Articles in Press |
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2025-04-18 07:26 |
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Publication Fee Transferred |
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2025-04-02 13:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-30 02:54 |
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Publish the Manuscript Online |
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2025-06-13 13:39 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Tao Wang, Yu-Le Yong, Ze-Kun Liu, Yi-Xuan Shen, Xiang-Min Yang and Zhi-Nan Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82002940 and No. 82203336 |
| Shaanxi Natural Science Foundation |
No. 2023-JC-YB-166 |
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| Corresponding Author |
Zhi-Nan Chen, PhD, Professor, Department of Cell Biology, National Translational Science Center for Molecular Medicine, The Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. znchen@fmmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Regulator of chromosome condensation 1; Proliferation; Cell cycle; Cell division cycle-associated 8; Phosphoinositide 3-kinase/protein kinase B pathway |
| Core Tip |
In this study, we investigated the role of regulator of chromosome condensation 1 (RCC1) in promoting the proliferation of hepatocellular carcinoma (HCC) cells. Initially, we determined that RCC1 is significantly upregulated in HCC and correlates with poor prognosis. Subsequently, we demonstrated that RCC1 facilitates the G1/S phase transition by regulating cell division cycle-associated 8. Furthermore, our findings indicate that the RCC1/cycle-associated 8 axis promotes HCC proliferation via the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a signaling pathway. Collectively, this research elucidates the association between RCC1 and HCC and highlights the role of RCC1 in regulating the G1/S transition of the cell cycle. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
<p>Wang YT, Yong YL, Liu ZK, Shen YX, Yang XM, Chen ZN. Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling. <i>World J Gastrointest Oncol</i> 2025; 17(6): 106080</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/106080.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.106080 |
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