Publication Name	World Journal of Hepatology
Manuscript ID	106151
Country	China

Received	2025-03-05 11:33
Peer-Review Started	2025-03-07 01:39
To Make the First Decision
Return for Revision	2025-04-16 10:45
Revised	2025-04-26 11:12
Second Decision	2025-06-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-11 08:40
Articles in Press	2025-06-11 08:40
Publication Fee Transferred	2025-04-30 02:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-16 01:19
Publish the Manuscript Online	2025-07-25 12:09

ISSN	1948-5182 (online)
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Category	Anatomy & Morphology
Manuscript Type	Basic Study
Article Title	Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration
Manuscript Source	Unsolicited Manuscript
All Author List	Run Liu, Jin-Cheng Li, Shi-De Li, Jian-Di Li, Rong-Quan He, Gang Chen, Zhen-Bo Feng and Jia-Liang Wei
ORCID	Author(s) ORCID Number Run Liu http://orcid.org/0009-0009-5267-1985 Jian-Di Li http://orcid.org/0000-0001-7050-371X Rong-Quan He http://orcid.org/0000-0002-7752-2080 Gang Chen http://orcid.org/0000-0003-2402-2987 Zhen-Bo Feng http://orcid.org/0000-0001-6361-4198 Jia-Liang Wei http://orcid.org/0009-0000-7911-3750
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82260581
Corresponding Author	Zhen-Bo Feng, MD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com
Key Words	Rac family small GT Phase 3; Hepatocellular carcinoma; Immunohistochemistry; High-throughput sequencing; Clustered regularly interspaced short palindromic repeats screening
Core Tip	This study identifies Rac family small GTPase 3 (RAC3) as a critical oncogenic driver in hepatocellular carcinoma (HCC) through multi functional validation. RAC3 overexpression correlates with advanced tumor stage and poor prognosis (hazard ratio = 1.82), while clustered regularly interspaced short palindromic repeats screening confirms its necessity for HCC proliferation. Mechanistically, E2F transcription factor 1 transcriptionally activates RAC3, which drives cell-cycle dysregulation. These findings position RAC3 as a promising therapeutic target for combating chemotherapy resistance in HCC.
Publish Date	2025-07-25 12:09
Citation	<p>Liu R, Li JC, Li SD, Li JD, He RQ, Chen G, Feng ZB, Wei JL. Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration. <i>World J Hepatol</i> 2025; 17(7): 106151</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i7/106151.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i7.106151

Full Article (PDF)	WJH-17-106151-with-cover.pdf
Manuscript File	106151_Auto_Edited_090100.docx
Answering Reviewers	106151-answering-reviewers.pdf
Audio Core Tip	106151-audio.m4a
Biostatistics Review Certificate	106151-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106151-conflict-of-interest-statement.pdf
Copyright License Agreement	106151-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106151-foundation-statement.pdf
Institutional Review Board Approval Form or Document	106151-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106151-non-native-speakers.pdf
Supplementary Material	106151-supplementary-material.pdf
Peer-review Report	106151-peer-reviews.pdf
Scientific Misconduct Check	106151-scientific-misconduct-check.png
Scientific Editor Work List	106151-scientific-editor-work-list.pdf
CrossCheck Report	106151-crosscheck-report.pdf