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Articles Published Processes
7/25/2025 12:09:42 PM | Browse: 91 | Download: 484
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Received |
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2025-03-05 11:33 |
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Peer-Review Started |
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2025-03-07 01:39 |
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First Decision by Editorial Office Director |
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2025-04-16 10:45 |
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Return for Revision |
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2025-04-16 10:45 |
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Revised |
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2025-04-26 11:12 |
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Publication Fee Transferred |
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2025-04-30 02:56 |
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Second Decision by Editor |
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2025-06-11 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-11 08:40 |
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Articles in Press |
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2025-06-11 08:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-16 01:19 |
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Publish the Manuscript Online |
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2025-07-25 12:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anatomy & Morphology |
| Manuscript Type |
Basic Study |
| Article Title |
Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Run Liu, Jin-Cheng Li, Shi-De Li, Jian-Di Li, Rong-Quan He, Gang Chen, Zhen-Bo Feng and Jia-Liang Wei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82260581 |
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| Corresponding Author |
Zhen-Bo Feng, MD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fengzhenbo_gxmu@163.com |
| Key Words |
Rac family small GT Phase 3; Hepatocellular carcinoma; Immunohistochemistry; High-throughput sequencing; Clustered regularly interspaced short palindromic repeats screening |
| Core Tip |
This study identifies Rac family small GTPase 3 (RAC3) as a critical oncogenic driver in hepatocellular carcinoma (HCC) through multi functional validation. RAC3 overexpression correlates with advanced tumor stage and poor prognosis (hazard ratio = 1.82), while clustered regularly interspaced short palindromic repeats screening confirms its necessity for HCC proliferation. Mechanistically, E2F transcription factor 1 transcriptionally activates RAC3, which drives cell-cycle dysregulation. These findings position RAC3 as a promising therapeutic target for combating chemotherapy resistance in HCC. |
| Publish Date |
2025-07-25 12:09 |
| Citation |
Liu R, Li JC, Li SD, Li JD, He RQ, Chen G, Feng ZB, Wei JL. Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration. World J Hepatol 2025; 17(7): 106151 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i7/106151.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i7.106151 |
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