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Articles Published Processes
6/13/2025 1:39:33 PM | Browse: 4 | Download: 16
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Received |
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2025-02-19 09:54 |
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Peer-Review Started |
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2025-02-19 09:54 |
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To Make the First Decision |
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Return for Revision |
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2025-03-11 07:33 |
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Revised |
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2025-03-24 03:40 |
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Second Decision |
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2025-04-22 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-22 07:44 |
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Articles in Press |
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2025-04-22 07:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-03 03:56 |
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Publish the Manuscript Online |
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2025-06-13 13:39 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun-Zai Feng, Si-Quan Zhong, Shao-Wei Ye, Zheng Zheng, Hao Sun and Shi-Hai Zhou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shi-Hai Zhou, Associate Chief Physician, Department of Tumor Surgery, Zhongshan City People’s Hospital, No. 2 Sunwen East Road, Shiqi District, Zhongshan 528403, Guangdong Province, China. 13068120688@163.com |
| Key Words |
Colorectal cancer; Exosomes; MiR-425-5p; MiR-135b-3p; Immune modulation; Vascular permeability |
| Core Tip |
This study identifies exosomal miR-425-5p and miR-135b-3p as critical regulators of colorectal cancer (CRC) progression. These microRNAs (miRNAs) are significantly upregulated in CRC-derived exosomes and modulate the tumor microenvironment through distinct mechanisms. MiR-425-5p promotes immune suppression by inducing macrophage M2 polarization and skewing T cell differentiation toward pro-tumor subsets, while miR-135b-3p enhances vascular permeability and angiogenesis. Inhibition of these miRNAs in preclinical models significantly reduces tumor growth and metastasis, suggesting they represent promising therapeutic targets for CRC. The findings provide novel insights into exosomal miRNA-mediated immune modulation and vascular remodeling in CRC progression. |
| Publish Date |
2025-06-13 13:39 |
| Citation |
<p>Feng CZ, Zhong SQ, Ye SW, Zheng Z, Sun H, Zhou SH. Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion. <i>World J Gastrointest Oncol</i> 2025; 17(6): 106161</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i6/106161.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i6.106161 |
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