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Articles Published Processes
7/21/2025 9:42:32 AM | Browse: 260 | Download: 762
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Received |
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2025-02-25 03:43 |
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Peer-Review Started |
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2025-02-25 03:43 |
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First Decision by Editorial Office Director |
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2025-04-02 07:05 |
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Return for Revision |
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2025-04-02 07:05 |
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Revised |
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2025-06-12 06:35 |
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Publication Fee Transferred |
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2025-04-23 08:56 |
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Second Decision by Editor |
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2025-06-16 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-16 07:52 |
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Articles in Press |
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2025-06-16 07:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-16 02:00 |
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Publish the Manuscript Online |
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2025-07-21 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Andrej Feješ, Paulína Belvončíková, Emil Bečka, Tomáš Strečanský, Michal Pastorek, Jakub Janko, Barbora Filová, Pavel Babál, Katarína Šebeková, Veronika Borbélyová and Roman Gardlík |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Slovak Research and Development Agency |
APVV-21-0370 |
| Ministry of Education, Science, Research and Sport of the Slovak Republic |
VEGA 1/0706/25 and VEGA 1/0341/23 |
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| Corresponding Author |
Roman Gardlík, Associate Professor, Head, MD, PhD, Institute of Molecular Biomedicine, Comenius University Faculty of Medicine, Sasinkova 4, Bratislava 81108, Slovakia. roman.gardlik@fmed.uniba.sk |
| Key Words |
Cell-free DNA; Mouse models; Metabolic dysfunction-associated steatotic liver disease; Neutrophil extracellular traps; Steatohepatitis; Myeloperoxidase; Neutrophil elastase |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern with limited therapeutic options. This study demonstrated that extracellular DNA (ecDNA) and neutrophil extracellular traps (NETs) serve as potential biomarkers of liver injury severity in MASLD. Using three distinct animal models, we showed that NET markers, including myeloperoxidase and ecDNA, correlated with liver fibrosis and inflammation. These findings highlighted NETs and ecDNA as promising targets for early diagnosis and intervention in MASLD, offering new insights into disease progression and potential therapeutic strategies. |
| Publish Date |
2025-07-21 09:42 |
| Citation |
Feješ A, Belvončíková P, Bečka E, Strečanský T, Pastorek M, Janko J, Filová B, Babál P, Šebeková K, Borbélyová V, Gardlík R. Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(27): 106166
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| URL |
https://www.wjgnet.com/1007-9327/full/v31/i27/106166.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i27.106166 |
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