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Articles Published Processes
5/16/2025 7:21:11 AM | Browse: 101 | Download: 565
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Received |
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2025-02-19 09:38 |
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Peer-Review Started |
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2025-02-19 09:39 |
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First Decision by Editorial Office Director |
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2025-03-05 11:48 |
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Return for Revision |
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2025-03-05 11:48 |
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Revised |
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2025-03-18 08:30 |
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Publication Fee Transferred |
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2025-03-25 07:58 |
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Second Decision by Editor |
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2025-04-17 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-04-17 09:11 |
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Articles in Press |
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2025-04-17 09:11 |
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Edit the Manuscript by Language Editor |
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2025-04-27 06:26 |
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Typeset the Manuscript |
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2025-05-08 01:08 |
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Publish the Manuscript Online |
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2025-05-16 07:21 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Jie Wang, Zhong-Zheng Zhi, Tao Liu, Jian Kang and Guang-Hui Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Major Research plan from the Health Commission of Hongkou District, ShangHai, China |
2001-03 |
| Academic subject boosting plan in the Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine, Shanghai, China |
SY-XKZT-2020-1003 |
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| Corresponding Author |
Jian Kang, MD, Department of Spine Surgery, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Department of Orthopedics
Shanghai Fourth People's Hospital
School of Medicine, Tongji University
Shanghai, PR China, Shanghai 200434, China. kangjian_spine@126.com |
| Key Words |
Spinal cord injury; Long non-coding RNA; Growth arrest-specific transcript 5; MicroRNA-21; Neuronal apoptosis |
| Core Tip |
This study investigates the role of long non-coding RNA growth arrest-specific transcript 5 (GAS5) in spinal cord injury (SCI)-induced neuronal apoptosis. We demonstrate that GAS5 acts as a molecular sponge to bind miR-21, thereby upregulating PTEN expression and inhibiting the AKT signaling pathway, ultimately promoting neuronal apoptosis. Inhibiting GAS5 expression alleviates neuronal apoptosis and improves motor function recovery in SCI rat models, suggesting that targeting GAS5 may be a promising therapeutic strategy for SCI. |
| Publish Date |
2025-05-16 07:21 |
| Citation |
Wang YJ, Zhi ZZ, Liu T, Kang J, Xu GH. Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis. World J Orthop 2025; 16(5): 106183 |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i5/106183.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i5.106183 |
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