Publication Name	World Journal of Clinical Oncology
Manuscript ID	106197
Country	China

Received	2025-02-19 12:35
Peer-Review Started	2025-02-19 12:35
To Make the First Decision
Return for Revision	2025-03-24 10:18
Revised	2025-04-03 13:09
Second Decision	2025-05-07 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-07 12:45
Articles in Press	2025-05-07 12:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-09 01:04
Publish the Manuscript Online	2025-06-20 08:05

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	NOTCH1 combined with chemotherapy synergistically inhibits triple-negative breast cancer
Manuscript Source	Invited Manuscript
All Author List	Wen-Jia Chen, Hua-Tao Wu, Yang-Zheng Lan, Zheng Wu, Xin-Ning Yu, Wen-Ting Lin and Jing Liu
ORCID	Author(s) ORCID Number Wen-Jia Chen http://orcid.org/0000-0001-7157-3242 Hua-Tao Wu http://orcid.org/0000-0002-1640-6094 Yang-Zheng Lan http://orcid.org/0009-0000-4241-228X Zheng Wu http://orcid.org/0000-0002-1393-7586 Xin-Ning Yu http://orcid.org/0009-0003-4658-4275 Jing Liu http://orcid.org/0000-0002-7483-4572
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82273457 the Natural Science Foundation of Guangdong Province 2021A1515012180 the Natural Science Foundation of Guangdong Province 2023A1515012762 Science and Technology Special Project of Guangdong Province 210715216902829 Science and Technology Special Project of Guangdong Province 200628175260810 ‘Dengfeng Project’ for the Construction of High-Level Hospitals in Guangdong Province—First Affiliated Hospital of Shantou University College Supporting Funding 202003-10
Corresponding Author	Jing Liu, Associate Professor, MD, PhD, The Breast Center, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Key Words	NOTCH1; Triple-negative breast cancer; Cisplatin; Sensitivity; NT5E
Core Tip	Chemoresistance in triple-negative breast cancer (TNBC) hampers chemotherapy effectiveness. This study shows that targeting NOTCH1 reduced cell proliferation and migration, enhancing cisplatin sensitivity. A positive correlation between NOTCH1 and NT5E expression was observed, with NT5E contributing to tumor progression and chemoresistance. NOTCH1 silencing downregulated NT5E, while NT5E overexpression partially reversed these effects. These findings suggest that targeting the NOTCH1-NT5E pathway could improve chemotherapy outcomes in TNBC.
Publish Date	2025-06-20 08:05
Citation	<p>Chen WJ, Wu HT, Lan YZ, Wu Z, Yu XN, Lin WT, Liu J. NOTCH1 combined with chemotherapy synergistically inhibits triple-negative breast cancer. <i>World J Clin Oncol</i> 2025; 16(6): 106197</p>
URL	https://www.wjgnet.com/2218-4333/full/v16/i6/106197.htm
DOI	https://dx.doi.org/10.5306/wjco.v16.i6.106197

Full Article (PDF)	WJCO-16-106197-with-cover.pdf
The ARRIVE Guidelines	106197-The-ARRIVE-Guidelines.pdf
Manuscript File	106197_Auto_Edited_055915.docx
Answering Reviewers	106197-answering-reviewers.pdf
Audio Core Tip	106197-audio.m4a
Biostatistics Review Certificate	106197-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106197-conflict-of-interest-statement.pdf
Copyright License Agreement	106197-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106197-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	106197-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	106197-non-native-speakers.pdf
Peer-review Report	106197-peer-reviews.pdf
Scientific Misconduct Check	106197-scientific-misconduct-check.png
Scientific Editor Work List	106197-scientific-editor-work-list.pdf
CrossCheck Report	106197-crosscheck-report.pdf