Publication Name	World Journal of Methodology
Manuscript ID	106216
Country	Greece

Received	2025-02-21 07:01
Peer-Review Started	2025-02-26 05:37
To Make the First Decision
Return for Revision	2025-04-18 01:12
Revised	2025-04-27 13:21
Second Decision	2025-06-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-27 03:47
Articles in Press	2025-06-27 03:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-07 09:05
Publish the Manuscript Online	2025-08-04 12:11

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Effect of alpha-tocopherol and OTR-4131 on muscle degeneration after rotator cuff tear in rats: An experimental protocol
Manuscript Source	Invited Manuscript
All Author List	Stavros Stamiris, Angeliki Cheva, Michael Potoupnis, Elissavet Anestiadou, Dimitrios Stamiris, Chryssa Bekiari, Antonia Loukousia, Papavasiliou Kyriakos, Eleftherios Tsiridis and Ioannis Sarris
ORCID	Author(s) ORCID Number Stavros Stamiris http://orcid.org/0000-0001-8543-6791 Angeliki Cheva http://orcid.org/0000-0002-5374-1772 Michael Potoupnis http://orcid.org/0000-0002-1236-5176 Elissavet Anestiadou http://orcid.org/0000-0001-5650-7319 Dimitrios Stamiris http://orcid.org/0000-0002-8558-1523 Chryssa Bekiari http://orcid.org/0000-0003-0600-3889 Antonia Loukousia http://orcid.org/0000-0003-3991-0645 Eleftherios Tsiridis http://orcid.org/0000-0001-8278-1653 Ioannis Sarris http://orcid.org/0000-0002-4599-258X
Funding Agency and Grant Number
Corresponding Author	Elissavet Anestiadou, MD, Fourth Academic Department of Surgery, School of Medical, Aristotle University of Thessaloniki, Leoforos Papanikolaou, Thessaloniki 54124, Greece. elissavetxatz@gmail.com
Key Words	Alpha-tocopherol; OTR-4131; Rotator cuff tears; Experimental protocol; Muscle atrophy; Fatty infiltration
Core Tip	This experimental protocol outlines a novel approach to investigating the use of therapeutic agents, following massive rotator cuff tears in a rat model. By systematically assessing muscle atrophy, fatty infiltration, and fibrosis, this study aims to establish a standardized methodology for evaluating potential therapeutic agents. The findings from this protocol could provide critical insights into muscle preservation strategies, potentially informing future preclinical and clinical interventions for rotator cuff repair.
Publish Date	2025-08-04 12:11
Citation	<p>Stamiris S, Cheva A, Potoupnis M, Anestiadou E, Stamiris D, Bekiari C, Loukousia A, Kyriakos P, Tsiridis E, Sarris I. Effect of alpha-tocopherol and OTR-4131 on muscle degeneration after rotator cuff tear in rats: An experimental protocol. <i>World J Methodol</i> 2025; 15(4): 106216</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i4/106216.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i4.106216

Full Article (PDF)	WJM-15-106216-with-cover.pdf
The ARRIVE Guidelines	106216-The-ARRIVE-Guidelines.pdf
Manuscript File	106216_Auto_Edited_090046.docx
Answering Reviewers	106216-answering-reviewers.pdf
Audio Core Tip	106216-audio.mp3
Biostatistics Review Certificate	106216-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106216-conflict-of-interest-statement.pdf
Copyright License Agreement	106216-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	106216-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	106216-non-native-speakers.pdf
Peer-review Report	106216-peer-reviews.pdf
Scientific Misconduct Check	106216-scientific-misconduct-check.png
Scientific Editor Work List	106216-scientific-editor-work-list.pdf
CrossCheck Report	106216-crosscheck-report.pdf