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Articles Published Processes
7/25/2025 12:09:45 PM | Browse: 21 | Download: 53
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Received |
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2025-02-20 04:05 |
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Peer-Review Started |
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2025-02-20 04:05 |
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To Make the First Decision |
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Return for Revision |
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2025-03-14 18:28 |
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Revised |
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2025-03-26 15:53 |
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Second Decision |
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2025-06-23 02:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-24 03:10 |
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Articles in Press |
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2025-06-24 03:10 |
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Publication Fee Transferred |
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2025-04-15 11:34 |
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Edit the Manuscript by Language Editor |
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2025-06-27 20:10 |
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Typeset the Manuscript |
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2025-07-16 01:21 |
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Publish the Manuscript Online |
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2025-07-25 12:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Case Report |
| Article Title |
Autoimmune hepatitis with syncytial giant cells in chronic lymphocytic leukemia: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marta Giacomelli, Simone Carotti, Federico Vozella, Federica Pagliei, Chiara Taffon, Andrea Baiocchini, Francesco Luigi Gambaro, Antonio Picardi, Umberto Vespasiani-Gentilucci and Giovanni Galati |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Giovanni Galati, Chief Physician, Operative Research Unit of Clinical Medicine and Hepatology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, Rome 00128, Italy. g.galati@policlinicocampus.it |
| Key Words |
Chronic lymphocytic leukemia; Autoimmune hepatitis; Syncytial giant cell hepatitis; Toll-like receptor 4; Multinucleated liver cells; Mycophenolate mofetil; Liver biopsy; Case report |
| Core Tip |
The association between chronic lymphocytic leukemia (CLL) and syncytial giant cell hepatitis (GCH) is rare, with only a few cases reported in the literature. For this reason, early diagnosis is essential to prevent liver fibrosis and to distinguish GCH from other causes of liver disorders. Active immunosuppressive therapy may be beneficial for GCH patients, with mycophenolate mofetil emerging as a promising therapeutic option. Several studies have suggested a modified expression of toll-like receptors (TLR) in CLL, potentially contributing to autoimmune complications. Further studies are needed to evaluate the role of TLR4 in autoimmune hepatitis development in CLL patients. |
| Publish Date |
2025-07-25 12:09 |
| Citation |
<p>Giacomelli M, Carotti S, Vozella F, Pagliei F, Taffon C, Baiocchini A, Gambaro FL, Picardi A, Vespasiani-Gentilucci U, Galati G. Autoimmune hepatitis with syncytial giant cells in chronic lymphocytic leukemia: A case report and review of literature. <i>World J Hepatol</i> 2025; 17(7): 106253</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i7/106253.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i7.106253 |
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