Publication Name	World Journal of Stem Cells
Manuscript ID	106272
Country	China

Received	2025-02-21 07:13
Peer-Review Started	2025-02-25 00:42
To Make the First Decision
Return for Revision	2025-03-25 08:03
Revised	2025-04-02 14:58
Second Decision	2025-06-12 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-12 09:27
Articles in Press	2025-06-12 09:27
Publication Fee Transferred	2025-04-07 04:27
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-17 08:34
Publish the Manuscript Online	2025-06-25 10:17

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Hematology
Manuscript Type	Basic Study
Article Title	Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Zhang, Bao-Dong Gao, Yuan Su, Wen-Jing Mi, Tong-Xu Zeng, Fei-Fei Ma and Xiao-Qin Ha
ORCID	Author(s) ORCID Number Bo Zhang http://orcid.org/0009-0004-8020-7120 Xiao-Qin Ha http://orcid.org/0000-0002-3280-413X
Funding Agency and Grant Number	Funding Agency Grant Number Major Science and Technology Project of Gansu Province - Social Development Field 25ZDFA007 Health Industry Research Funding Project of Gansu Province GSWSKY2024-54 Youth Science and Technology Fund Program of Gansu Province 21JR11RA014 National Natural Science Foundation of China 81273568 Health Industry Research Funding Project of Gansu Province GSWSKY2022-03 Logistics Scientific Research Independent Project of the PLA
Corresponding Author	Xiao-Qin Ha, Clinical Laboratory, The 940th Hospital of the PLA Joint Logistics Support Force, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730000, Gansu Province, China. haxiaoqin2013@163.com
Key Words	Human umbilical cord mesenchymal stem cells; High-altitude; Hypoxia; Platelets; Platelet α-granules
Core Tip	The effects of human umbilical cord mesenchymal stem cell (hUC-MSC) on platelet α-granules in rats during acute exposure to high-altitude hypoxia were assessed. hUC-MSCs significantly reduced platelet counts and plasma levels of von Willebrand factor, platelet factor 4, and beta-thromboglobulin, as well as the expression of CD62p on platelet surfaces. Additionally, hUC-MSCs improved platelet morphology and reduced pseudopodia formation and α-granule contents. These effects were mediated by activation of the protein kinase B/mitogen-activated protein kinase/extracellular-signal regulated kinase signaling pathway. The findings suggest that hUC-MSCs may represent a promising preventive strategy against acute high-altitude-associated thrombosis, and provide empirical support for their expanded clinical application.
Publish Date	2025-06-25 10:17
Citation	<p>Zhang B, Gao BD, Su Y, Mi WJ, Zeng TX, Ma FF, Ha XQ. Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia. <i>World J Stem Cells</i> 2025; 17(6): 106272</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i6/106272.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i6.106272

Full Article (PDF)	WJSC-17-106272-with-cover.pdf
The ARRIVE Guidelines	106272-The-ARRIVE-Guidelines.pdf
Manuscript File	106272_Auto_Edited_074507.docx
Answering Reviewers	106272-answering-reviewers.pdf
Audio Core Tip	106272-audio.mp3
Biostatistics Review Certificate	106272-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106272-conflict-of-interest-statement.pdf
Copyright License Agreement	106272-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106272-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	106272-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	106272-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106272-non-native-speakers.pdf
Peer-review Report	106272-peer-reviews.pdf
Scientific Misconduct Check	106272-scientific-misconduct-check.png
Scientific Editor Work List	106272-scientific-editor-work-list.pdf
CrossCheck Report	106272-crosscheck-report.pdf