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Articles Published Processes
6/25/2025 10:17:07 AM | Browse: 140 | Download: 724
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Received |
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2025-02-21 07:13 |
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Peer-Review Started |
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2025-02-25 00:42 |
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First Decision by Editorial Office Director |
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2025-03-25 08:03 |
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Return for Revision |
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2025-03-25 08:03 |
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Revised |
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2025-04-02 14:58 |
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Publication Fee Transferred |
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2025-04-07 04:27 |
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Second Decision by Editor |
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2025-06-12 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-06-12 09:27 |
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Articles in Press |
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2025-06-12 09:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-17 08:34 |
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Publish the Manuscript Online |
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2025-06-25 10:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Basic Study |
| Article Title |
Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Zhang, Bao-Dong Gao, Yuan Su, Wen-Jing Mi, Tong-Xu Zeng, Fei-Fei Ma and Xiao-Qin Ha |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major Science and Technology Project of Gansu Province - Social Development Field |
25ZDFA007 |
| Health Industry Research Funding Project of Gansu Province |
GSWSKY2024-54 |
| Youth Science and Technology Fund Program of Gansu Province |
21JR11RA014 |
| National Natural Science Foundation of China |
81273568 |
| Health Industry Research Funding Project of Gansu Province |
GSWSKY2022-03 |
| Logistics Scientific Research Independent Project of the PLA |
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| Corresponding Author |
Xiao-Qin Ha, Clinical Laboratory, The 940th Hospital of the PLA Joint Logistics Support Force, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730000, Gansu Province, China. haxiaoqin2013@163.com |
| Key Words |
Human umbilical cord mesenchymal stem cells; High-altitude; Hypoxia; Platelets; Platelet α-granules |
| Core Tip |
The effects of human umbilical cord mesenchymal stem cell (hUC-MSC) on platelet α-granules in rats during acute exposure to high-altitude hypoxia were assessed. hUC-MSCs significantly reduced platelet counts and plasma levels of von Willebrand factor, platelet factor 4, and beta-thromboglobulin, as well as the expression of CD62p on platelet surfaces. Additionally, hUC-MSCs improved platelet morphology and reduced pseudopodia formation and α-granule contents. These effects were mediated by activation of the protein kinase B/mitogen-activated protein kinase/extracellular-signal regulated kinase signaling pathway. The findings suggest that hUC-MSCs may represent a promising preventive strategy against acute high-altitude-associated thrombosis, and provide empirical support for their expanded clinical application. |
| Publish Date |
2025-06-25 10:17 |
| Citation |
Zhang B, Gao BD, Su Y, Mi WJ, Zeng TX, Ma FF, Ha XQ. Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia. World J Stem Cells 2025; 17(6): 106272 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i6/106272.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i6.106272 |
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