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Articles Published Processes
9/24/2025 3:48:39 AM | Browse: 15 | Download: 32
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Received |
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2025-02-26 08:10 |
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Peer-Review Started |
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2025-03-04 00:06 |
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To Make the First Decision |
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Return for Revision |
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2025-03-19 02:01 |
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Revised |
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2025-03-27 10:40 |
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Second Decision |
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2025-08-29 00:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-05 06:51 |
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Articles in Press |
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2025-09-05 06:51 |
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Publication Fee Transferred |
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2025-04-03 13:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 07:55 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Zhang, Qing Huang and Kai-Feng Gan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kai-Feng Gan, Department of Orthopedics, The Affiliated Lihuili Hospital of Ningbo University, No. 57 Xingning Road, Ningbo 315211, Zhejiang Province, China. gankaifeng@163.com |
| Key Words |
Tendon-bone healing; Bone mesenchymal stromal cells; Exosome; Lactate dehydrogenase A; Histone lactylation modification; Cartilage fragments |
| Core Tip |
This study reveals that lactate dehydrogenase A (LDHA) in exosomes from bone marrow mesenchymal stem cells significantly enhances tendon-bone healing after anterior cruciate ligament reconstruction. LDHA promotes chondrocyte stem cell proliferation and differentiation by increasing lactate secretion and upregulating bone morphogenetic protein 7 via histone H3K18 lactylation. High LDHA expression boosts cartilage and fibrocartilage regeneration, accelerates new bone formation, and reverses bone morphogenetic protein 7 knockdown effects. These findings highlight LDHA-rich exosomes from bone marrow mesenchymal stem cells as a promising therapeutic strategy for improving anterior cruciate ligament reconstruction outcomes. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Zhang T, Huang Q, Gan KF. Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration. <i>World J Stem Cells</i> 2025; 17(9): 106282</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/106282.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.106282 |
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