Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106316
Country	China

Received	2025-02-24 12:45
Peer-Review Started	2025-02-24 12:45
To Make the First Decision
Return for Revision	2025-03-20 07:39
Revised	2025-03-27 12:47
Second Decision	2025-04-22 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-22 06:50
Articles in Press	2025-04-22 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-24 01:47
Typeset the Manuscript	2025-05-30 03:28
Publish the Manuscript Online	2025-06-13 13:39

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Molecular surveillance-informed therapy in Lynch syndrome of personalized multidisciplinary approach achieving prolonged cancer survival: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Xin Xu, Yun-He Gao, Cheng-Zhou Du, Xiao-Xin Gao, Peng Chen, Rui-Fang Fan, Hong-Tao Li and Zhi Qiao
ORCID	Author(s) ORCID Number Xin-Xin Xu http://orcid.org/0000-0002-0855-5962 Hong-Tao Li http://orcid.org/0000-0003-0628-6874 Zhi Qiao http://orcid.org/0000-0002-2158-4901
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972790 Natural Science Foundation of Gansu Province, China 22JR5RA004
Corresponding Author	Zhi Qiao, Professor, Department of General Surgery & Institute of General Surgery, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. drqiaozhi@126.com
Key Words	Lynch syndrome; Colorectal cancer; Precision medicine; Multidisciplinary treatment; Case report
Core Tip	This case report spotlights the critical value of a personalized, multidisciplinary approach in managing Lynch syndrome - associated colorectal cancer. It underscores how precision medicine, particularly immunotherapy with programmed death protein 1 inhibitors, and rigorous molecular surveillance can lead to markedly improved patient outcomes, including sustained clinical remission for over 30 months. The integration of these strategies sets a new precedent for treating this complex genetic disorder.
Publish Date	2025-06-13 13:39
Citation	<p>Xu XX, Gao YH, Du CZ, Gao XX, Chen P, Fan RF, Li HT, Qiao Z. Molecular surveillance-informed therapy in Lynch syndrome of personalized multidisciplinary approach achieving prolonged cancer survival: A case report. <i>World J Gastrointest Oncol</i> 2025; 17(6): 106316</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i6/106316.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i6.106316

Full Article (PDF)	WJGO-17-106316-with-cover.pdf
CARE Checklist–2016	106316-CARE-Checklist-2016.pdf
Manuscript File	106316_Auto_Edited_074736.docx
Answering Reviewers	106316-answering-reviewers.pdf
Audio Core Tip	106316-audio.wav
Conflict-of-Interest Disclosure Form	106316-conflict-of-interest-statement.pdf
Copyright License Agreement	106316-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106316-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	106316-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	106316-non-native-speakers.pdf
Peer-review Report	106316-peer-reviews.pdf
Scientific Misconduct Check	106316-scientific-misconduct-check.png
Scientific Editor Work List	106316-scientific-editor-work-list.pdf
CrossCheck Report	106316-crosscheck-report.pdf