Publication Name	World Journal of Gastroenterology
Manuscript ID	10639
Country	Italy

Received	2014-04-11 08:35
Peer-Review Started	2014-04-11 17:40
To Make the First Decision	2014-05-29 18:56
Return for Revision	2014-06-03 17:13
Revised	2014-06-24 18:55
Second Decision	2014-07-16 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-16 13:09
Articles in Press	2014-07-16 17:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-24 10:01
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Human Papillomavirus does not have a causal role in colorectal carcinogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Laura Lorenzon, Francesca Mazzetta, Emanuela Pilozzi, Giordana Uggeri, Maria Rosaria Torrisi, Mario Ferri, Vincenzo Ziparo and Deborah French
Funding Agency and Grant Number	Funding Agency Grant Number PhD University Grant program “Clinical and Experimental Research Methodologies in Oncology” to Lorenzon L MIUR and AIRC - Associazione Italiana per la Ricerca sul Cancro, Italy IG 10272
Corresponding Author	Laura Lorenzon, MD, PhD, Surgical and Medical Department of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Sant’Andrea Hospital of Rome, Via di Grottarossa 1035-39, 00189 Rome, Italy. laura.lorenzon@uniroma1.it
Key Words	Colorectal cancer; Human papillomavirus; Carcinogenesis; W12
Core Tip	The burden of human papillomavirus (HPV)-associated cancers is not limited to the cervix, but includes the oropharynx and the ano-genital area. Moreover, emerging studies have reported the detection of HPV DNA in the tumoral mucosae of several epithelia, including the colorectum. This is the first study aimed to investigate the presence of HPV in specimens using clinically validated methodology, and it is the first to apply the molecular basis of HPV-related carcinogenesis. Because we only detected episomal HPV16s in low quantities, and it was transcriptionally inactive, we conclude that the virus unlikely plays a role in colorectal carcinogenesis.
Publish Date	2015-01-07 11:07
Citation	Lorenzon L, Mazzetta F, Pilozzi E, Uggeri G, Torrisi MR, Ferri M, Ziparo V, French D. Human Papillomavirus does not have a causal role in colorectal carcinogenesis. World J Gastroenterol 2015; 21(1): 342-350
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/342.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.342

Full Article (PDF)	WJG-21-342.pdf
Full Article (Word)	WJG-21-342.doc
Manuscript File	10639-Review.docx
Answering Reviewers	10639-Answering reviewers.pdf
Copyright License Agreement	10639-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10639-Language certificate.pdf
Peer-review Report	10639-Peer reviews.pdf
Scientific Misconduct Check	10639-CrossCheck.jpg
Scientific Editor Work List	10639-Scientific editor work list.pdf