| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Intestinal fibrosis attenuates the prophylactic effect of anti-tumour necrosis factor therapy on the postoperative recurrence of Crohn’s disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ze-Yu Ding, Yu-Jie Wang, Dan-Hua Yao, Tao Tian, Yu-Hua Huang and You-Sheng Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82200621 |
| Original Research Projects, Shanghai Ninth People’s Hospital |
2022LHA08, YBKB202220 |
|
| Corresponding Author |
You-Sheng Li, MD, PhD, Professor, Department of General Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People’s Hospital, No. 639 Zhizaoju Road, Huangpu District, Shanghai 200023, China. gisurgery9@126.com |
| Key Words |
Crohn’s disease; Resection; Postoperative recurrence; Biologic therapy; Intestinal fibrosis |
| Core Tip |
In a real-world cohort of Crohn’s disease patients with curative ileocecal resection, endoscopic postoperative recurrence (POR), radiographical POR and surgical POR rates were 52.6%, 41.2%, and 10.8%, respectively. Intestinal fibrosis increased the risk of radiographical POR and surgical POR despite biologic prophylaxis. After adjusting for disease severity, fibrosis was significantly associated with accelerated rPOR progression. Higher serum trough levels may delay endoscopic POR onset. These findings highlight the need for improved treatments for patients with Crohn’s disease with prolonged disease and fibrosis. |
| Publish Date |
2025-08-25 12:36 |
| Citation |
<p>Ding ZY, Wang YJ, Yao DH, Tian T, Huang YH, Li YS. Intestinal fibrosis attenuates the prophylactic effect of anti-tumour necrosis factor therapy on the postoperative recurrence of Crohn’s disease. <i>World J Gastrointest Surg</i> 2025; 17(8): 106455</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i8/106455.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i8.106455 |
