Publication Name	World Journal of Diabetes
Manuscript ID	106470
Country	China

Received	2025-02-27 11:47
Peer-Review Started	2025-03-03 00:10
To Make the First Decision
Return for Revision	2025-04-08 07:06
Revised	2025-04-20 16:21
Second Decision	2025-05-27 10:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 09:36
Articles in Press	2025-06-09 09:36
Publication Fee Transferred	2025-04-21 13:55
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-03 01:06
Publish the Manuscript Online	2025-07-15 08:26

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Clinical Trials Study
Article Title	Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Ruo-Man Sun, De-Xing Dai, Feng Xu, Ya-Li Ling and Zhong-Jian Xie
ORCID	Author(s) ORCID Number Zhong-Jian Xie http://orcid.org/0000-0002-1601-1156
Funding Agency and Grant Number	Funding Agency Grant Number National Key R and D Program of China No. 2021YFC2501700 National Key R and D Program of China No. 2021YFC2501705 National Natural Science Foundation of China No. 82171580 National Natural Science Foundation of China No. 81672646
Corresponding Author	Zhong-Jian Xie, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Disease, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha 410011, Hunan Province, China. zhongjian.xie@csu.edu.cn
Key Words	Continuous subcutaneous insulin infusion; Insulin dose; Multiple daily injections; Type 2 diabetes; Glycemic control
Core Tip	This study demonstrates that patients with type 2 diabetes mellitus (T2DM) on continuous subcutaneous insulin infusion require a lower dose of insulin than those receiving multiple daily injections, while achieving good glycemic control. Fasting plasma glucose, glycated hemoglobin, body mass index, and waist circumference correlated with increased insulin requirements across both therapies. Our data also suggest that the ratio of total basal insulin dose to total daily dose of approximately 40% (lower than the 50% recommended percentage) may optimize glycemic outcomes. These findings highlight the need for careful selection of insulin therapy and revision of basal insulin recommendations in T2DM management.
Publish Date	2025-07-15 08:26
Citation	<p>Sun RM, Dai DX, Xu F, Ling YL, Xie ZJ. Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes. <i>World J Diabetes</i> 2025; 16(7): 106470</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i7/106470.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i7.106470

Full Article (PDF)	WJD-16-106470-with-cover.pdf
CONSORT 2010 Statement	106470-CONSORT-2010-statement.pdf
Manuscript File	106470_Auto_Edited_064424.docx
Answering Reviewers	106470-answering-reviewers.pdf
Audio Core Tip	106470-audio.mp3
Biostatistics Review Certificate	106470-biostatistics-statement.pdf
Clinical Trial Registration Statement	106470-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	106470-conflict-of-interest-statement.pdf
Copyright License Agreement	106470-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106470-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	106470-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	106470-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106470-non-native-speakers.pdf
Peer-review Report	106470-peer-reviews.pdf
Journal Editor-in-Chief Review Report	106470-journal-editor-in-chief.pdf
Scientific Misconduct Check	106470-scientific-misconduct-check.png
Scientific Editor Work List	106470-scientific-editor-work-list.pdf
CrossCheck Report	106470-crosscheck-report.pdf