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Articles Published Processes
6/26/2025 7:27:58 AM | Browse: 149 | Download: 689
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Received |
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2025-02-27 11:50 |
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Peer-Review Started |
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2025-03-10 00:47 |
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First Decision by Editorial Office Director |
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2025-03-28 09:49 |
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Return for Revision |
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2025-03-28 09:49 |
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Revised |
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2025-04-24 16:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-05-29 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-05-29 09:18 |
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Articles in Press |
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2025-05-29 09:18 |
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Edit the Manuscript by Language Editor |
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2025-06-04 18:16 |
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Typeset the Manuscript |
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2025-06-16 07:29 |
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Publish the Manuscript Online |
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2025-06-26 07:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Laboratory Technology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Diagnostic performance of Liver FibraChek Dx©, a blood-based test for the non-invasive detection of liver cirrhosis and cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fernando Siguencia, Michitaka Matsuda, Vijay Pandyarajan, Sunao Tanaka, Steven M Smith, Catherine Bresee, Ekihiro Seki, Charles J Rosser and Hideki Furuya |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hideki Furuya, Associate Professor, PhD, Department of Biomedical Science, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States. hideki.furuya@cshs.org |
| Key Words |
Biomarkers; Metabolic dysfunction-associated steatotic liver disease; Cirrhosis; Multiplex; Metabolomics; Peripheral blood; Hepatocellular carcinoma; Fibrosis; High pressure liquid chromatography |
| Core Tip |
This retrospective observational study assessed the diagnostic accuracy of Liver FibraChek Dx©, a non-invasive serum assay for detecting metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). The test algorithm integrates five serum biomarkers and age to produce a risk score. Among 45 participants with biopsy-confirmed diagnoses (MASLD, HCC, or healthy), Liver FibraChek Dx© achieved an area under the receiver operating characteristic curve of 0.890, with 93.9% sensitivity and 88.9% accuracy. Risk scores significantly distinguished individuals with liver disease from healthy controls. These findings support the potential clinical utility of Liver FibraChek Dx© in diagnosing and monitoring liver pathogenesis via blood-based testing. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
Siguencia F, Matsuda M, Pandyarajan V, Tanaka S, Smith SM, Bresee C, Seki E, Rosser CJ, Furuya H. Diagnostic performance of Liver FibraChek Dx©, a blood-based test for the non-invasive detection of liver cirrhosis and cancer. World J Hepatol 2025; 17(6): 106481 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/106481.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.106481 |
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