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Articles Published Processes
6/25/2025 10:17:04 AM | Browse: 6 | Download: 16
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Received |
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2025-02-28 15:13 |
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Peer-Review Started |
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2025-03-04 01:50 |
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To Make the First Decision |
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Return for Revision |
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2025-04-01 12:41 |
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Revised |
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2025-04-14 03:16 |
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Second Decision |
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2025-05-21 02:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-28 07:21 |
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Articles in Press |
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2025-05-28 07:21 |
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Publication Fee Transferred |
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2025-04-18 13:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-08 06:17 |
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Publish the Manuscript Online |
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2025-06-25 10:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Li Wang, Ming-Yue Ouyang, Zi-En Yang, Si-Ning Xing, Song Zhao and Hui-Ying Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
2024-MS-250 |
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| Corresponding Author |
Hui-Ying Yu, PhD, Laboratory of Basic Medicine, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. hyingy@sina.com |
| Key Words |
Mesenchymal stem cells; Exosomes; Radiation induced pulmonary fibrosis; Protein kinase B; Nuclear factor kappa B |
| Core Tip |
Mesenchymal stem cells-derived exosomes were demonstrated protective properties against radiation induced pulmonary fibrosis in rat models and lung epithelial cell models. Moreover, these exosomes were shown to reverse the expression of key components involved in the buildup of extracellular matrix and epithelial-mesenchymal transition due to radiation by inhibiting the protein kinase B/nuclear factor kappa B pathway. This inhibition prevented fibrosis progression and facilitated the recovery and proliferation of damaged lung epithelial cells. These findings offer new insights into potential treatment strategies for radiation-induced pulmonary fibrosis. |
| Publish Date |
2025-06-25 10:17 |
| Citation |
<p>Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY. Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. <i>World J Stem Cells</i> 2025; 17(6): 106488</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i6/106488.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i6.106488 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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