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Articles Published Processes
6/26/2025 7:27:52 AM | Browse: 148 | Download: 563
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Received |
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2025-02-27 12:00 |
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Peer-Review Started |
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2025-03-03 00:09 |
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First Decision by Editorial Office Director |
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2025-03-19 09:50 |
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Return for Revision |
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2025-03-19 09:50 |
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Revised |
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2025-03-30 02:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-04-23 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-04-23 11:01 |
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Articles in Press |
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2025-04-23 11:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 08:02 |
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Publish the Manuscript Online |
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2025-06-26 07:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Silent sabotage: How hepatitis B virus-miR-3 disarms innate immunity through cGAS-STING suppression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nida Ansari and Patrick Twohig |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Patrick Twohig, Assistant Professor, FRCPC, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14682, United States. patrick_twohig@urmc.rochester.edu |
| Key Words |
Hepatitis B; MicroRNA; Gene expression; Immunity; Treatment |
| Core Tip |
Hepatitis B virus (HBV) evades innate immunity through HBV-miR-3, which suppresses the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-IFN pathway, a critical antiviral defense mechanism. By downregulating cGAS and STING, HBV prevents interferon production, allowing the virus to persist and promoting chronic infection. Targeting HBV-miR-3 or restoring this immune pathway could offer new therapeutic strategies to enhance antiviral immunity and combat HBV-related diseases. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
Ansari N, Twohig P. Silent sabotage: How hepatitis B virus-miR-3 disarms innate immunity through cGAS-STING suppression. World J Hepatol 2025; 17(6): 106493 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/106493.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.106493 |
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