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Articles Published Processes
6/25/2025 10:17:05 AM | Browse: 142 | Download: 679
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Received |
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2025-02-28 15:03 |
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Peer-Review Started |
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2025-03-03 00:07 |
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First Decision by Editorial Office Director |
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2025-03-27 10:37 |
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Return for Revision |
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2025-03-27 10:37 |
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Revised |
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2025-04-02 14:23 |
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Publication Fee Transferred |
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2025-04-03 05:24 |
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Second Decision by Editor |
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2025-05-30 02:35 |
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Second Decision by Editor-in-Chief |
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2025-06-01 06:29 |
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Final Decision by Editorial Office Director |
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2025-06-03 09:14 |
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Articles in Press |
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2025-06-03 09:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-08 06:18 |
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Publish the Manuscript Online |
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2025-06-25 10:17 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Qiu Ye, Xiao-Hu Meng, Xin Fang, Han-Yi Liu and Hassan Hamisi Mwindadi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hangzhou Bio-Medicine and Health Industry Development Support Science and Technology Project |
2022WJC005, 2024WJC105 |
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| Corresponding Author |
Xiao-Hu Meng, Department of Vascular Surgery, The First People’s Hospital of Hangzhou Affiliated to Westlake University, No. 261 Huansha Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. 1193970654@qq.com |
| Key Words |
Mesenchymal stem cells; Carotid atherosclerosis; MiR-126; Mitogen-activated protein kinases/extracellular signal-regulated kinase signaling pathway; Angiogenesis; Endothelial differentiation; Vascular repair |
| Core Tip |
Carotid atherosclerosis is closely linked to endothelial dysfunction, a relationship validated in rat models. As traditional drugs fall short in curing the disease and surgery carries risks, researchers are exploring gene-based therapies. MiR-126 emerges as a potential therapeutic factor. Experiments show it promotes mesenchymal stem cell differentiation into endothelial cells. Molecularly, miR-126 synergizes with the mitogen-activated protein kinases/extracellular signal-regulated kinase pathway. By modulating this pathway, miR-126 suppresses atherosclerotic lesion progression and shows promise in enhancing vascular health. These findings underscore the potential of miR-126 mimics in treating carotid atherosclerosis, laying a foundation for clinical translation. |
| Publish Date |
2025-06-25 10:17 |
| Citation |
Ye ZQ, Meng XH, Fang X, Liu HY, Mwindadi HH. MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway. World J Stem Cells 2025; 17(6): 106520 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i6/106520.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i6.106520 |
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