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Articles Published Processes
6/26/2025 7:27:53 AM | Browse: 2 | Download: 10
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Received |
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2025-03-03 15:46 |
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Peer-Review Started |
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2025-03-04 01:56 |
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To Make the First Decision |
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Return for Revision |
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2025-04-09 12:49 |
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Revised |
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2025-04-15 12:58 |
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Second Decision |
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2025-05-13 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-13 08:28 |
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Articles in Press |
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2025-05-13 08:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-16 08:03 |
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Publish the Manuscript Online |
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2025-06-26 07:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunkumar Krishnan and Diptasree Mukherjee |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arunkumar Krishnan, MD, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com |
| Key Words |
Zinc finger protein 71; Hepatocellular carcinoma; Biomarkers; Genomic data; Prognostic value; Functional validation; Clustered regularly interspaced short palindromic repeats; Tumor progression |
| Core Tip |
A study by Qin et al showed significant upregulation of zinc finger protein 71 (ZNF71) in hepatocellular carcinoma and its association with disease progression. While their findings are valuable, limitations include the need for diverse patient cohorts, larger non-cancerous tissue samples, and functional validation through in vitro and in vivo studies. Statistical improvements, multivariate regression, and multiple comparison corrections are essential. Future research should integrate genomic, epigenomic, and tumor microenvironment data while comparing ZNF71 with established biomarkers like alpha-fetoprotein. Addressing these gaps will strengthen ZNF71’s potential as a diagnostic and therapeutic target in hepatocellular carcinoma. |
| Publish Date |
2025-06-26 07:27 |
| Citation |
<p>Krishnan A, Mukherjee D. Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions. <i>World J Hepatol</i> 2025; 17(6): 106573</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i6/106573.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i6.106573 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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