Publication Name	World Journal of Methodology
Manuscript ID	106591
Country	Denmark

Received	2025-03-04 13:07
Peer-Review Started	2025-03-14 00:16
To Make the First Decision
Return for Revision	2025-04-01 05:06
Revised	2025-04-12 08:34
Second Decision	2025-06-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-10 10:53
Articles in Press	2025-06-10 10:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-17 19:21
Typeset the Manuscript	2025-07-07 10:21
Publish the Manuscript Online	2025-08-04 12:11

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Preoperative marking of the proximal resection margin in esophageal cancer with a surgical fiducial marker-first experiences
Manuscript Source	Invited Manuscript
All Author List	Trygve U Solstad, Andreas W Mucha, August A Olsen, Hanne Grossjohann and Michael P Achiam
ORCID	Author(s) ORCID Number Trygve U Solstad http://orcid.org/0000-0002-6457-1174 Andreas W Mucha http://orcid.org/0000-0002-9617-9521 August A Olsen http://orcid.org/0000-0002-6893-6863 Michael P Achiam http://orcid.org/0000-0002-3062-5138
Funding Agency and Grant Number	Funding Agency Grant Number Nanovi A/S to twenty vials of BioXmark® along with financial support for the evaluation of the implementation of the fiducial marker
Corresponding Author	Trygve U Solstad, MD, Researcher, Department of Digestive Diseases, Transplantation and General Surgery, Copenhagen University Hospital Rigshospitalet, Inge Lehmannsvej 7, Copenhagen 2100, 2100, København, Denmark. trygve.ulvund.solstad.01@regionh.dk
Key Words	BioXmark®; Gastroesophageal junction cancer; Gastroesophageal surgery; Surgical oncology; Fiducial marker
Core Tip	This study explores the use of BioXmark®, a liquid fiducial marker, to enhance precision in cancer surgery. BioXmark® was injected five centimeters proximal to the tumor during a preoperative nasal gastroscopy. The injected BioXmark® was subsequently identified in vivo using perioperative ultrasound. By improving intraoperative visualization of tumor margins, fiducial markers may increase the precision of resection and likelihood of achieving an R0 resection, potentially reducing patient morbidity and mortality. The marker's technical feasibility and safety were demonstrated, although further studies are needed to optimize its visibility and clinical application.
Publish Date	2025-08-04 12:11
Citation	<p>Solstad TU, Mucha AW, Olsen AA, Grossjohann H, Achiam MP. Preoperative marking of the proximal resection margin in esophageal cancer with a surgical fiducial marker-first experiences. <i>World J Methodol</i> 2025; 15(4): 106591</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i4/106591.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i4.106591

Full Article (PDF)	WJM-15-106591-with-cover.pdf
STROBE Statement	106591-STROBE-statement.pdf
Manuscript File	106591_Auto_Edited_071258.docx
Answering Reviewers	106591-answering-reviewers.pdf
Audio Core Tip	106591-audio.mp3
Biostatistics Review Certificate	106591-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106591-conflict-of-interest-statement.pdf
Copyright License Agreement	106591-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106591-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	106591-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	106591-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106591-non-native-speakers.pdf
Peer-review Report	106591-peer-reviews.pdf
Scientific Misconduct Check	106591-scientific-misconduct-check.png
Scientific Editor Work List	106591-scientific-editor-work-list.pdf
CrossCheck Report	106591-crosscheck-report.pdf