Publication Name	World Journal of Gastroenterology
Manuscript ID	10664
Country	Türkiye

Received	2014-04-12 18:09
Peer-Review Started	2014-04-12 20:19
To Make the First Decision	2014-05-13 20:39
Return for Revision	2014-05-21 08:48
Revised	2014-06-03 00:00
Second Decision	2014-07-11 16:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-11 17:26
Articles in Press	2014-07-11 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-25 16:46
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations
Manuscript Source	Invited Manuscript
All Author List	Dilek Cevik, Gokhan Yildiz and Mehmet Ozturk
Funding Agency and Grant Number	Funding Agency Grant Number TUBITAK, the Scientific and Technological Research Council of Turkey 113S389 TUBITAK BIDEB-2211 TUBITAK BIDEB-2211 TUBITAK BIDEB-2214 EMBO short term fellowships
Corresponding Author	Mehmet Ozturk, PhD, Professor of Medical Biology, Advanced Biomedical Research Center, Dokuz Eylul University, Balcova, Izmir 35340, Turkey. mehmet.ozturk@deu.edu.tr
Key Words	Hepatocellular carcinoma; Liver cancer; Telomerase reverse transcriptase; Promoter mutation; Cellular immortality; Telomerase reverse transcriptase gene
Core Tip	Our study demonstrated that telomerase reverse transcriptase (TERT) promoter mutations are present in hepatocellular carcinomas (HCCs) from different geographical regions, and the highest frequency was observed in tumors from Africa. These mutations occur both primarily as C228T mutation and as C250T mutation. These results also provide evidence for TERT mutations as a common trait of HCC regardless of their geographical location.
Publish Date	2015-01-07 11:07
Citation	Cevik D, Yildiz G, Ozturk M. Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations. World J Gastroenterol 2015; 21(1): 311-317
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/311.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.311

Full Article (PDF)	WJG-21-311.pdf
Full Article (Word)	WJG-21-311.doc
Manuscript File	10664-Review.doc
Answering Reviewers	10664-Answering Reviewers.pdf
Copyright License Agreement	10664-Copyright Assignment.pdf
Peer-review Report	10664-Peer reviews.pdf
Scientific Misconduct Check	10664-CrossCheck.jpg
Scientific Editor Work List	10664-Scientific editor work list.pdf