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Articles Published Processes
8/14/2025 5:49:35 AM | Browse: 95 | Download: 308
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Received |
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2025-03-04 05:17 |
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Peer-Review Started |
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2025-03-04 05:17 |
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First Decision by Editorial Office Director |
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2025-04-08 07:43 |
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Return for Revision |
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2025-04-08 09:41 |
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Revised |
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2025-04-08 16:14 |
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Publication Fee Transferred |
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2025-04-13 07:34 |
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Second Decision by Editor |
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2025-07-04 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-04 08:50 |
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Articles in Press |
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2025-07-04 08:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 07:35 |
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Publish the Manuscript Online |
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2025-08-14 05:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Megan Wern-Ee Chua and Dedrick Kok-Hong Chan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dedrick Kok-Hong Chan, Department of Colorectal Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. surckhd@nus.edu.sg |
| Key Words |
Cell free DNA; Circulating tumour deoxyribonucleic acid; Colorectal cancer; Liquid biopsy; Screening; Detection; Prognostication |
| Core Tip |
Cell free DNA (cfDNA) carries information about colorectal cancer-specific genetic and epigenetic alterations which can aid in screening, detection and prognostication. Detection of genetic alterations is made difficult by low signal-to-noise ratio owing to an abundance of background non-tumorigenic mutations. Low amounts of cfDNA in healthy individuals negatively affects the sequencing performance and limit of detection of assays making screening non-feasible. One solution is to harvest cfDNA from peritoneal fluid or stool as this is more representative of the primary tumour compared to plasma-derived cfDNA. Alternatively, increasing the sensitivity of sequencing technologies would allow for the detection of low frequency mutations. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
Chua MWE, Chan DKH. Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer. World J Gastrointest Oncol 2025; 17(8): 106663 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/106663.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.106663 |
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