BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/14/2025 5:49:35 AM | Browse: 15 | Download: 22
 |
Received |
|
2025-03-04 05:17 |
|
Peer-Review Started |
|
2025-03-04 05:17 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-04-08 09:41 |
|
Revised |
|
2025-04-08 16:14 |
|
Second Decision |
|
2025-07-04 02:35 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-07-04 08:50 |
|
Articles in Press |
|
2025-07-04 08:50 |
|
Publication Fee Transferred |
|
2025-04-13 07:34 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-08-01 07:35 |
|
Publish the Manuscript Online |
|
2025-08-14 05:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Megan Wern-Ee Chua and Dedrick Kok-Hong Chan |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dedrick Kok-Hong Chan, Department of Colorectal Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. surckhd@nus.edu.sg |
| Key Words |
Cell free DNA; Circulating tumour deoxyribonucleic acid; Colorectal cancer; Liquid biopsy; Screening; Detection; Prognostication |
| Core Tip |
Cell free DNA (cfDNA) carries information about colorectal cancer-specific genetic and epigenetic alterations which can aid in screening, detection and prognostication. Detection of genetic alterations is made difficult by low signal-to-noise ratio owing to an abundance of background non-tumorigenic mutations. Low amounts of cfDNA in healthy individuals negatively affects the sequencing performance and limit of detection of assays making screening non-feasible. One solution is to harvest cfDNA from peritoneal fluid or stool as this is more representative of the primary tumour compared to plasma-derived cfDNA. Alternatively, increasing the sensitivity of sequencing technologies would allow for the detection of low frequency mutations. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Chua MWE, Chan DKH. Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer. <i>World J Gastrointest Oncol</i> 2025; 17(8): 106663</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/106663.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.106663 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
