| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Higher HbA1c amplifies the effect of APOE4-related cognition and olfaction impairments in type 2 diabetes: A multicenter study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Rong Wang, Yang Gao, Yan-Chao Liu, Zhi-Peng Xu, Yu-Ying Wang, Hai-Bo Xu, Jian-Zhi Wang and Yao Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Postdoctoral Science Foundation General Program |
No. 2024M762504 |
| Intramural Research Program of Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology |
No. 2023 LYYYGZRP0004 |
|
| Corresponding Author |
Yao Zhang, Department of Endocrinology, Li-Yuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Qiaokou District, Wuhan 430077, Hubei Province, China. zhangyaodoc@163.com |
| Key Words |
Glycated hemoglobin; Apolipoprotein E epsilon 4; Type 2 diabetes mellitus; Cognitive impairment; Olfactory function |
| Core Tip |
This study explores how the Apolipoprotein E epsilon 4 (APOE4) genotype and glycated hemoglobin (HbA1c) levels influence cognitive and olfactory performance in individuals with Type 2 diabetes mellitus (T2DM). The findings suggest that APOE4 is linked to both cognitive and olfactory deficits, and that elevated HbA1c levels further intensify these effects. Rather than serving as a mediator, HbA1c modifies the relationship, strengthening the adverse impact of APOE4. These results indicate that both APOE4 and poor glycemic control contribute to neurofunctional decline, underscoring the importance of early intervention in at-risk diabetic populations. |
| Publish Date |
2025-08-14 10:51 |
| Citation |
<p>Wang YR, Gao Y, Liu YC, Xu ZP, Wang YY, Xu HB, Wang JZ, Zhang Y. Higher HbA1c amplifies the effect of APOE4-related cognition and olfaction impairments in type 2 diabetes: A multicenter study. <i>World J Diabetes</i> 2025; 16(8): 106664</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i8/106664.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i8.106664 |
