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Articles Published Processes
4/14/2025 7:02:36 AM | Browse: 15 | Download: 29
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Received |
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2025-03-04 12:33 |
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Peer-Review Started |
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2025-03-05 02:46 |
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2025-03-20 09:08 |
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2025-03-20 13:50 |
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Second Decision |
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2025-04-02 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-02 06:25 |
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Articles in Press |
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2025-04-02 06:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-04-09 02:53 |
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Publish the Manuscript Online |
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2025-04-14 07:02 |
| ISSN |
1948-5190 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunkumar Krishnan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arunkumar Krishnan, MD, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com |
| Key Words |
Crohn's disease; Leucine-rich alpha-2 glycoprotein; Biomarkers; Small bowel lesions; Inflammatory bowel disease; Disease monitoring; Precision medicine |
| Core Tip |
A recent study by Ohno et al indicated that leucine-rich alpha-2 glycoprotein (LRG) has potential as a biomarker for identifying small bowel lesions in Crohn's disease. However, several methodological challenges are required to be addressed. The retrospective nature, the lack of direct comparisons with fecal calprotectin, and the absence of long-term data highlight the need for further validation. Moreover, there is potential for improving the utility of LRG by integrating it with other biomarkers and artificial intelligence to improve its effectiveness in disease monitoring. Future research should address interobserver variability, assess the cost-effectiveness, and standardize definitions for endoscopic healing. |
| Publish Date |
2025-04-14 07:02 |
| Citation |
<p>Krishnan A. Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward. <i>World J Gastrointest Endosc</i> 2025; 17(4): 106671</p> |
| URL |
https://www.wjgnet.com/1948-5190/full/v17/i4/106671.htm |
| DOI |
https://dx.doi.org/10.4253/wjge.v17.i4.106671 |
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