| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Iron dysregulation, ferroptosis, and oxidative stress in diabetic osteoporosis: Mechanisms, bone metabolism disruption, and therapeutic strategies
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yao-Bin Wang, Zhi-Peng Li, Peng Wang, Rui-Bo Wang, Yu-Hua Ruan, Zhen Shi, Hao-Yu Li, Jin-Ke Sun, Yang Mi, Cheng-Jin Li, Peng-Yuan Zheng and Chang-Jiang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province Key Research and Development Program |
231111311000 |
| Henan Provincial Science and Technology Research Project |
232102310411 |
| Henan Province Medical Science and Technology Key Project |
LHGJ20220566 |
| Henan Province Medical Science and Technology Key Project |
LHGJ20240365 |
| Henan Province Medical Education Research Project |
WJLX2023079 |
| Zhengzhou Medical and Health Technology Innovation Guidance Program |
2024YLZDJH022 |
|
| Corresponding Author |
Chang-Jiang Zhang, Chief Physician, Professor, The Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. changjiangzhang1968@outlook.com |
| Key Words |
Bone metabolism; Bone mineral density; Diabetes-related osteoporosis; Hyperglycemia; Inflammatory response; Iron-dependent cell death; Iron metabolism dysregulation; Osteoblasts; Osteoclasts; Oxidative stress |
| Core Tip |
Diabetic osteoporosis (DOP) is becoming increasingly prevalent, driven by global aging and diabetes-related metabolic disturbances. Elevated glucose levels impair osteoblast function and activate osteoclasts via oxidative stress and chronic inflammation, accelerating bone loss. Dysregulated iron metabolism, particularly iron overload, triggers ferroptosis - a novel form of cell death marked by lipid peroxidation and reactive oxygen species production-further exacerbating DOP. Therapeutic strategies targeting iron metabolism and ferroptosis, including antioxidants, iron chelators, and personalized interventions, hold significant potential for improving bone health. Future research should prioritize unraveling underlying mechanisms and refining targeted treatment approaches. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
<p>Wang YB, Li ZP, Wang P, Wang RB, Ruan YH, Shi Z, Li HY, Sun JK, Mi Y, Li CJ, Zheng PY, Zhang CJ. Iron dysregulation, ferroptosis, and oxidative stress in diabetic osteoporosis: Mechanisms, bone metabolism disruption, and therapeutic strategies. <i>World J Diabetes</i> 2025; 16(6): 106720</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/106720.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.106720 |
