Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	106724
Country	Türkiye

Received	2025-03-06 10:09
Peer-Review Started	2025-03-06 10:09
To Make the First Decision
Return for Revision	2025-03-31 09:03
Revised	2025-03-31 19:52
Second Decision	2025-05-19 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-19 07:59
Articles in Press	2025-05-19 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-05-23 02:36
Typeset the Manuscript	2025-06-30 14:12
Publish the Manuscript Online	2025-07-23 11:10

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice
Manuscript Source	Invited Manuscript
All Author List	Hikmet Pehlevan-Özel, Eda Şahingöz, Mert Altaş and Mesut Tez
ORCID	Author(s) ORCID Number Hikmet Pehlevan-Özel http://orcid.org/0000-0002-9146-3742 Eda Şahingöz http://orcid.org/0009-0004-1773-3080 Mert Altaş http://orcid.org/0009-0007-9807-8031 Mesut Tez http://orcid.org/0000-0001-5282-9492
Funding Agency and Grant Number
Corresponding Author	Mesut Tez, Professor, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye. mesuttez@yahoo.com
Key Words	Rectal cancer; Neoadjuvant chemoradiotherapy; Pathological complete response; Biomarkers; Tumor regression grading; Clinical predictors; Radiomics
Core Tip	This review synthesizes biomarkers predicting neoadjuvant chemoradiotherapy response in rectal cancer, including clinical predictors (e.g., tumor size, nodal status), histopathological features (e.g., tumor regression grading), molecular markers (e.g., KRAS mutations), microenvironmental factors (e.g., tumor-infiltrating lymphocytes), and radiomics, to guide personalized treatment and improve outcomes.
Publish Date	2025-07-23 11:10
Citation	<p>Pehlevan-Özel H, Şahingöz E, Altaş M, Tez M. Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice. <i>World J Gastrointest Surg</i> 2025; 17(7): 106724</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i7/106724.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i7.106724

Full Article (PDF)	WJGS-17-106724-with-cover.pdf
Manuscript File	106724_Auto_Edited_062610.docx
Answering Reviewers	106724-answering-reviewers.pdf
Audio Core Tip	106724-audio.mp4
Conflict-of-Interest Disclosure Form	106724-conflict-of-interest-statement.pdf
Copyright License Agreement	106724-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	106724-non-native-speakers.pdf
Peer-review Report	106724-peer-reviews.pdf
Scientific Misconduct Check	106724-scientific-misconduct-check.png
Scientific Editor Work List	106724-scientific-editor-work-list.pdf
CrossCheck Report	106724-crosscheck-report.pdf