BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/28/2025 7:32:57 AM | Browse: 5 | Download: 34
 |
Received |
|
2025-03-06 09:08 |
|
Peer-Review Started |
|
2025-03-06 09:08 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-04-01 06:39 |
|
Revised |
|
2025-04-12 15:11 |
|
Second Decision |
|
2025-05-12 02:38 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-05-12 05:33 |
|
Articles in Press |
|
2025-05-12 05:33 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-05-20 07:09 |
|
Publish the Manuscript Online |
|
2025-05-28 07:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Applications and challenges of patient-derived organoids in hepatobiliary and pancreatic cancers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Wei Hu, Yan-Zhi Pan, Xiao-Xiao Zhang, Jiang-Tao Li and Yun Jin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Research and Development Program of Zhejiang Province |
No. 2024C03172 |
| Clinical Medical Research Special Fund Project of Zhejiang Medical Association |
No. 2024ZYC-Z50 |
|
| Corresponding Author |
Yun Jin, Associate Chief Physician, MD, Department of Hepatic-Biliary-Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. jinyunzeyy@zju.edu.cn |
| Key Words |
Patient-derived tumor organoids; Hepatobiliary and pancreatic cancers; Tumor microenvironment; Co-culture; Drug prediction |
| Core Tip |
Hepatobiliary and pancreatic (HBP) cancers are highly aggressive, with recurrence and metastasis driven by tumor heterogeneity and drug resistance, posing significant treatment challenges. Current personalized and accurate prediction models are lacking. Patient-derived organoids (PDOs) tumor, three-dimensional in vitro models from patient tumor tissues, show over 70% cultivation success and over 90% predictive accuracy. However, PDOs face limitations in simulating the tumor microenvironment despite advances in co-culture and microfluidic techniques. Additionally, PDOs' potential in predicting multi-drug therapy efficacy requires further assessment. This review outlines the applications and challenges of organoid models in HBP cancer research. |
| Publish Date |
2025-05-28 07:32 |
| Citation |
<p>Hu JW, Pan YZ, Zhang XX, Li JT, Jin Y. Applications and challenges of patient-derived organoids in hepatobiliary and pancreatic cancers. <i>World J Gastroenterol</i> 2025; 31(20): 106747</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i20/106747.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i20.106747 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
