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Articles Published Processes
5/30/2025 10:57:32 AM | Browse: 14 | Download: 16
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Received |
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2025-03-11 02:21 |
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Peer-Review Started |
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2025-03-11 02:21 |
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To Make the First Decision |
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Return for Revision |
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2025-03-31 15:02 |
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Revised |
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2025-04-03 06:25 |
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Second Decision |
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2025-05-12 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-12 08:50 |
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Articles in Press |
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2025-05-12 08:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-26 00:37 |
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Publish the Manuscript Online |
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2025-05-30 10:57 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Dong, San-Xiong Huang, Mo-Liang Qin and Zhuo Pan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhuo Pan, Chief Physician, Hepatobiliary Pancreatic Surgery, Huzhou First People's Hospital, Huzhou First People's Hospital, Huzhou 532322, Zhejiang Province, China. m18267851073@163.com |
| Key Words |
Intestinal ischemia-reperfusion injury; Ferroptosis; Histone lactylation; Mitochondrial alanyl-tRNA synthetase 2; Acyl-CoA synthetase long-chain family member 4; Epigenetic regulation; Lipid peroxidation; Intestinal barrier dysfunction; Reactive oxygen species; Cell death |
| Core Tip |
This investigation reveals mitochondrial alanyl-tRNA synthetase 2 (AARS2) as a pivotal regulator of ferroptotic cell death in intestinal ischemia-reperfusion (I/R) injury. Our findings demonstrate that AARS2 augments histone H3K18 lactylation modification, which subsequently drives the transcriptional upregulation of acyl-CoA synthetase long-chain family member 4 through chromatin remodeling. This molecular cascade potentiates the accumulation of lipid peroxidation products and exacerbates intestinal epithelial damage. Pharmacological inhibition of AARS2 effectively suppresses ferroptosis progression and maintains mucosal barrier integrity, establishing its clinical relevance for managing I/R-associated tissue injury. |
| Publish Date |
2025-05-30 10:57 |
| Citation |
<p>Dong W, Huang SX, Qin ML, Pan Z. Mitochondrial alanyl-tRNA synthetase 2 mediates histone lactylation to promote ferroptosis in intestinal ischemia-reperfusion injury. <i>World J Gastrointest Surg</i> 2025; 17(6): 106777</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i6/106777.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i6.106777 |
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