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8/20/2025 8:41:24 AM | Browse: 58 | Download: 79
Publication Name World Journal of Clinical Oncology
Manuscript ID 106838
Country United States
Received
2025-03-09 07:58
Peer-Review Started
2025-03-09 07:58
To Make the First Decision
Return for Revision
2025-03-28 19:36
Revised
2025-03-31 03:40
Second Decision
2025-07-01 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-02 02:35
Articles in Press
2025-07-02 02:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-07 02:32
Publish the Manuscript Online
2025-08-20 08:41
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Cell reprogramming in cancer: Interplay of genetic, epigenetic mechanisms, and the tumor microenvironment in carcinogenesis and metastasis
Manuscript Source Invited Manuscript
All Author List Santosh Shenoy
ORCID
Author(s) ORCID Number
Santosh Shenoy http://orcid.org/0000-0001-6117-1151
Funding Agency and Grant Number
Corresponding Author Santosh Shenoy, Consultant, FACS, Professor, Department of Surgery, Kansas City VA Medical Center, University of Missouri-Kansas City, 4801 E Linwood, Kansas, MO 64128, United States. shenoy2009@hotmail.com
Key Words AlphaFold; Deep learning; Artificial intelligence; Chemotherapy resistance; Tumorigenesis; Cell reprogramming
Core Tip The idea of deregulated cell plasticity being considered a hallmark of cancer emphasizes the adaptive nature of tumors, their ability to evade homeostatic regulation, and their capacity for resilience in the face of therapeutic intervention. Understanding the cell reprogramming mechanisms that drive this plasticity could ultimately lead to the development of more effective therapies that target these adaptive processes and prevent the tumor from exploiting its ability to continuously evolve and resist treatment. Google’s AlphaFold represents a game-changer in chemotherapy drug discovery by providing a fast and accurate method to predict protein structures, enabling researchers to identify new drug targets, design better molecules, and understand the complex biology of cancer at a level of detail that was previously unattainable. By integrating next-generation sequencing and single-cell RNA sequencing, artificial intelligence-driven deep learning models, and AlphaFold’s predictions with experimental data and existing drug discovery techniques, we could see faster development of more effective, specific, chemotherapy agents in the future. By merging these technologies, precise, durable, and truly personalized cancer therapy could become a clinical reality, revolutionizing the way we approach cancer treatment.
Publish Date 2025-08-20 08:41
Citation <p>Shenoy S. Cell reprogramming in cancer: Interplay of genetic, epigenetic mechanisms, and the tumor microenvironment in carcinogenesis and metastasis. <i>World J Clin Oncol</i> 2025; 16(8): 106838</p>
URL https://www.wjgnet.com/2218-4333/full/v16/i8/106838.htm
DOI https://dx.doi.org/10.5306/wjco.v16.i8.106838
Full Article (PDF) WJCO-16-106838-with-cover.pdf
Manuscript File 106838_Auto_Edited_014710.docx
Answering Reviewers 106838-answering-reviewers.pdf
Audio Core Tip 106838-audio.m4a
Conflict-of-Interest Disclosure Form 106838-conflict-of-interest-statement.pdf
Copyright License Agreement 106838-copyright-assignment.pdf
Peer-review Report 106838-peer-reviews.pdf
Scientific Misconduct Check 106838-scientific-misconduct-check.png
Scientific Editor Work List 106838-scientific-editor-work-list.pdf
CrossCheck Report 106838-crosscheck-report.pdf