| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Bile spillage in incidental gallbladder cancer is not an independent predictor for survival: A multi-institute retrospective cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mike van Dooren, Elise AJ de Savornin Lohman, Rachel S van der Post, Frederik JH Hoogwater, Peter B van den Boezem, Bas Groot Koerkamp, Joris I Erdmann and Philip R de Reuver |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation ADP |
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| Corresponding Author |
Mike van Dooren, MD, Department of Surgery, Radboud University Medical Center, P.O. Box 9101, Internal Code 618, Nijmegen 6500 HB, Gelderland, Netherlands. mike.vandooren@radboudumc.nl |
| Key Words |
Gallbladder; Gall bladder; Carcinoma; Cancer; Incidental; Bile spillage; Bile spill; Bile leakage; Bile leak; Survival |
| Core Tip |
In this retrospective cohort study, the relationship between bile spillage and survival in patients with incidental gallbladder carcinoma was analyzed in 32 Dutch hospitals. Bile spillage was associated with adverse prognostic factors, namely higher age, American Society of Anesthesiologists classification and T stage and non-radical resection. Unlike those other factors, bile spillage was not an independent predictor for survival in multivariable analysis. Additionally, in our cohort, bile spillage was linked to localized rather than peritoneal reoccurrence as described in existing literature. Patients with an indication for additional treatment should be referred to a specialised hepatopancreaticobiliary center, irrespective of whether bile spillage has occurred. |
| Publish Date |
2025-07-23 11:11 |
| Citation |
<p>Dooren MV, de Savornin Lohman EA, van der Post RS, Hoogwater FJ, van den Boezem PB, Groot Koerkamp B, Erdmann JI, de Reuver PR. Bile spillage in incidental gallbladder cancer is not an independent predictor for survival: A multi-institute retrospective cohort study. <i>World J Gastrointest Surg</i> 2025; 17(7): 106919</p> |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i7/106919.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i7.106919 |
