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Articles Published Processes
5/14/2025 5:24:53 AM | Browse: 4 | Download: 0
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Received |
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2025-03-11 02:30 |
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Peer-Review Started |
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2025-03-11 02:31 |
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To Make the First Decision |
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Return for Revision |
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2025-03-26 11:04 |
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Revised |
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2025-04-03 09:07 |
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Second Decision |
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2025-04-16 02:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-16 08:40 |
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Articles in Press |
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2025-04-16 08:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-05-06 02:34 |
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Publish the Manuscript Online |
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2025-05-14 05:24 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Laboratory Technology |
| Manuscript Type |
Editorial |
| Article Title |
Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dan-Dan Shi, Ju Tian and Jing Ding |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ju Tian, Burns and Plastic Surgery, ZhongshanCity People’s Hospital, Sunwen East Road, Zhongshan 528400, Guangdong Province, China. tian-ju@163.com |
| Key Words |
Pleural effusion; Pleural adenosine deaminase; Inflammatory; Pathophysiological; Diagnosis |
| Core Tip |
Maranhão et al introduce a standardized pleural adenosine deaminase (P-ADA) cutoff (≥ 9.00 U/L) for diagnosing inflammatory pleural effusions, validated via rigorous statistical analysis in a Brazilian cohort. This addresses inconsistencies in international reference values and links P-ADA to purinergic signaling and ADA2 isoform activation in macrophages and lymphocytes. The study emphasizes P-ADA’s clinical utility as a non-invasive, cost-effective biomarker to reduce the need for invasive procedures (e.g., thoracentesis) and improve diagnostic accuracy in resource-limited settings. Its integration into clinical workflows could streamline management, reduce healthcare costs, and enable early treatment stratification, pending multicenter validation for broader global application. |
| Publish Date |
2025-05-14 05:24 |
| Citation |
<p>Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. <i>World J Clin Cases</i> 2025; 13(22): 106925</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i22/106925.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i22.106925 |
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