Publication Name	World Journal of Stem Cells
Manuscript ID	106934
Country	South Korea

Received	2025-03-11 09:54
Peer-Review Started	2025-03-12 00:43
To Make the First Decision
Return for Revision	2025-03-27 10:38
Revised	2025-04-03 16:15
Second Decision	2025-05-07 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-07 05:27
Articles in Press	2025-05-07 05:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-16 07:39
Publish the Manuscript Online	2025-05-26 09:15

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Aberrant bone formation and dysregulated bone homeostasis in ankylosing spondylitis
Manuscript Source	Invited Manuscript
All Author List	Gun Woo Lee
ORCID	Author(s) ORCID Number Gun Woo Lee http://orcid.org/0000-0002-8441-0802
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Yeungnam University Research Grant
Corresponding Author	Gun Woo Lee, Associate Professor, MD, PhD, Department of Orthopedic Surgery, Yeungnam University College of Medicine, No. 170 Hyunchung-ro, Namgu, Daegu 42415, South Korea. gwlee1871@gmail.com
Key Words	Ankylosing spondylitis; Cytokines; Immune; Osteoclast; Pathway; Targeted therapy
Core Tip	In ankylosing spondylitis (AS), osteoclasts contribute significantly to pathological bone resorption and remodeling. The receptor activator of nuclear factor-kappa B/receptor activator of nuclear factor-kappa B ligand/osteoprotegerin signaling axis, inflammatory cytokines such as interleukin-17 and tumor necrosis factor-alpha, and immune cells such as T helper type 17 and macrophages are central to osteoclastogenesis in AS. Elucidation of the mechanisms governing osteoclast differentiation, activation, and dysregulation in AS is essential for the development of targeted therapeutic strategies that modulate aberrant bone remodeling.
Publish Date	2025-05-26 09:15
Citation	<p>Lee GW. Aberrant bone formation and dysregulated bone homeostasis in ankylosing spondylitis. <i>World J Stem Cells</i> 2025; 17(5): 106934</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i5/106934.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i5.106934

Full Article (PDF)	WJSC-17-106934-with-cover.pdf
Manuscript File	106934_Auto_Edited_083115.docx
Answering Reviewers	106934-answering-reviewers.pdf
Audio Core Tip	106934-audio.m4a
Conflict-of-Interest Disclosure Form	106934-conflict-of-interest-statement.pdf
Copyright License Agreement	106934-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106934-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	106934-non-native-speakers.pdf
Peer-review Report	106934-peer-reviews.pdf
Scientific Misconduct Check	106934-scientific-misconduct-check.png
Scientific Editor Work List	106934-scientific-editor-work-list.pdf
CrossCheck Report	106934-crosscheck-report.pdf