| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Miao-Xin Zhang, Chi Wu, Xin-Xia Feng, Wei Tian, Ning-Hui Zhao, Pan-Pan Lu, Qiang Ding and Mei Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
82002609 |
|
| Corresponding Author |
Mei Liu, MD, PhD, Professor, Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. fliumei@126.com |
| Key Words |
Esophageal stricture after endoscopic submucosal dissection; Celastrol; NLR family pyrin domain containing 3 inflammasome; Early-stage esophageal neoplasm; Natural medicine |
| Core Tip |
NLR family pyrin domain containing 3 (NLRP3) and interleukin-1β are increased in the endoscopic submucosal dissection resection bed of patients with esophageal neoplasms. Celastrol (CEL) prevented esophageal stricture in rats, and the effects were comparable to the positive control, prednisolone. Thioredoxin reductase 1 (TXNRD1) was increased by CEL in lipopolysaccharide plus ATP stimulated primary rat esophageal fibroblasts. Independent of its effect on reactive oxygen species, TXNRD1 interacts with NLRP3 and promotes its ubiquitination. |
| Publish Date |
2025-06-20 09:55 |
| Citation |
<p>Zhang MX, Wu C, Feng XX, Tian W, Zhao NH, Lu PP, Ding Q, Liu M. Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. <i>World J Gastroenterol</i> 2025; 31(23): 106949</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i23/106949.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i23.106949 |
