Publication Name	World Journal of Psychiatry
Manuscript ID	106971
Country	China

Received	2025-03-23 16:51
Peer-Review Started	2025-03-23 16:51
To Make the First Decision
Return for Revision	2025-05-07 05:30
Revised	2025-06-02 03:14
Second Decision	2025-06-24 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-24 09:07
Articles in Press	2025-06-24 09:07
Publication Fee Transferred	2025-06-03 07:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-21 01:45
Publish the Manuscript Online	2025-08-08 10:23

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychology, Clinical
Manuscript Type	Observational Study
Article Title	Diamine oxidase as a biomarker for depression and disease activity in inflammatory bowel disease: A cross-sectional observational study
Manuscript Source	Unsolicited Manuscript
All Author List	Su-Cong Lyu, Guo-Qiang Zhong, Run-Jie Shi, Yan Sun, Jin Li, Ming-Song Li and Ye Chen
ORCID	Author(s) ORCID Number Su-Cong Lyu http://orcid.org/0009-0001-3278-7421 Guo-Qiang Zhong http://orcid.org/0009-0005-8196-3013 Run-Jie Shi http://orcid.org/0009-0004-6912-966X Yan Sun http://orcid.org/0000-0001-9878-3055 Jin Li http://orcid.org/0000-0003-4576-6723 Ming-Song Li http://orcid.org/0000-0003-2115-5928 Ye Chen http://orcid.org/0000-0002-7964-7899
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270581 and 82270546
Corresponding Author	Ye Chen, MD, PhD, Professor, Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Baiyun Road North, Baiyun District, Guangzhou 510515, Guangdong Province, China. yechen@smu.edu.cn
Key Words	Diamine oxidase; Depression; Intestinal barrier dysfunction; Disease activity; Inflammatory bowel disease; Quality of life
Core Tip	Few studies have explored the association between markers of intestinal barrier dysfunction and psychological symptoms in patients with inflammatory bowel disease (IBD). Our study revealed that serum diamine oxidase (DAO) levels were significantly elevated in IBD patients with moderate-to-severe psychological symptoms as compared to those with no or mild psychological symptoms. Furthermore, correlation analysis indicated that DAO was positively associated with depression and negatively associated with quality of life in IBD patients. Additionally, receiver operating characteristic curves confirmed that DAO is associated with clinical disease activity in patients with IBD. This study suggests the potential of DAO as a novel biomarker for predicting psychological symptoms and disease activity in IBD.
Publish Date	2025-08-08 10:23
Citation	<p>Lyu SC, Zhong GQ, Shi RJ, Sun Y, Li J, Li MS, Chen Y. Diamine oxidase as a biomarker for depression and disease activity in inflammatory bowel disease: A cross-sectional observational study. <i>World J Psychiatry</i> 2025; 15(8): 106971</p>
URL	https://www.wjgnet.com/2220-3206/full/v15/i8/106971.htm
DOI	https://dx.doi.org/10.5498/wjp.v15.i8.106971

Full Article (PDF)	WJP-15-106971-with-cover.pdf
STROBE Statement	106971-STROBE-statement.pdf
Manuscript File	106971_Auto_Edited_025201.docx
Answering Reviewers	106971-answering-reviewers.pdf
Audio Core Tip	106971-audio.mp3
Biostatistics Review Certificate	106971-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	106971-conflict-of-interest-statement.pdf
Copyright License Agreement	106971-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	106971-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	106971-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	106971-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	106971-non-native-speakers.pdf
Supplementary Material	106971-supplementary-material.pdf
Peer-review Report	106971-peer-reviews.pdf
Scientific Editor Work List	106971-scientific-editor-work-list.pdf
CrossCheck Report	106971-crosscheck-report.pdf