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3/9/2015 3:58:00 PM | Browse: 681 | Download: 770
Publication Name World Journal of Gastroenterology
Manuscript ID 10698
Country/Territory United States
Received
2014-04-15 10:00
Peer-Review Started
2014-04-15 19:36
To Make the First Decision
2014-06-10 13:33
Return for Revision
2014-06-11 10:33
Revised
2014-07-12 13:34
Second Decision
2014-08-28 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-08-28 10:26
Articles in Press
2014-08-28 10:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-02-25 11:07
Publish the Manuscript Online
2015-03-09 15:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General and Internal
Manuscript Type Observational Study
Article Title Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups
Manuscript Source Unsolicited Manuscript
All Author List Christina M Hester, Venkatakrishna R Jala, Morgan GI Langille, Shahid Umar, K Allen Greiner and Bodduluri Haribabu
Funding Agency and Grant Number
Funding Agency Grant Number
University of Kansas Cancer Center U54CA154253
University of Kansas Clinical Translational Science Program CA123245
NCI at NIH 1R01CA138623
James Graham Brown Cancer Center, University of Louisville
Corresponding author Christina M Hester, PhD, Assistant Professor, Department of Family Medicine Research Division, University of Kansas Medical Center, Kansas City, MS 3064, 3901 Rainbow Boulevard, KS 66160, United States. chester@kumc.edu
Keywords Colorectal cancer; Short chain fatty acids; Racial/ethnic disparities; Butyrate; Microbiota
Core Tip This brief report describes analysis of stool samples from 20 adult participants aged 50 years and above using 16S rRNA pyrosequencing. We found significantly lower short chain fatty acid levels and significantly different microbial profiles in African Americans vs Whites. We also found a significant correlation between the predicted butyrate kinase levels based on 16S rRNA gene abundance and stool levels of butyrate. These results should be useful in future analysis of colorectal cancer incidence and mortality differentials across racial/ethnic groups.
Publish Date 2015-03-09 15:58
Citation Hester CM, Jala VR, Langille MGI, Umar S, Greiner KA, Haribabu B. Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups. World J Gastroenterol 2015; 21(9): 2759-2769
Url http://www.wjgnet.com/1007-9327/full/v21/i9/2759.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i9.2759
Full Article (PDF) WJG-21-2759.pdf
Full Article (Word) WJG-21-2759.doc
Manuscript File 10698-Review.docx
Answering Reviewers 10698-Answering reviewers.pdf
Copyright License Agreement 10698-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140414231834.pdf
Peer-review Report 10698-Peer review.pdf
Scientific Misconduct Check 10698-CorssCheck.jpg
Scientific Editor Work List 10698-Scientific editor work list.pdf