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Articles Published Processes
6/13/2025 11:47:49 AM | Browse: 85 | Download: 330
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Received |
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2025-03-13 12:41 |
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Peer-Review Started |
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2025-03-14 07:00 |
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First Decision by Editorial Office Director |
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2025-03-20 08:16 |
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Return for Revision |
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2025-03-20 08:16 |
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Revised |
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2025-03-22 07:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-04-02 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-04-02 05:34 |
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Articles in Press |
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2025-04-02 05:34 |
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Edit the Manuscript by Language Editor |
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2025-04-10 09:26 |
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Typeset the Manuscript |
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2025-05-29 14:23 |
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Publish the Manuscript Online |
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2025-06-13 11:47 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng Luo, Zhi-Gang Zheng, Mei-Qi Zeng, Hui Xu, Xian-Mei Yu, Da Sun and Dong-Juan He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Quzhou Science and Technology Plan Project |
2024K076 |
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| Corresponding Author |
Dong-Juan He, Chief Physician, Deputy Director, MD, Department of Endocrinology, The Second People’s Hospital of Quzhou, No. 338 Xin 'an Avenue, Qujiang District, Quzhou 324000, Zhejiang Province, China. hedongjuan1247@wmu.edu.cn |
| Key Words |
Curcumol; Diabetic retinopathy; Epigenetic regulation; FTO/MAFG-AS1 pathway; N6-methyladenosine modification; Metabolic memory; Nano-delivery system; Single-cell transcriptomics |
| Core Tip |
This study reveals curcumol's dual-action mechanism in diabetic retinopathy through FTO/MAFG-AS1 axis modulation and macrophage membrane-coated nanodelivery. Curcumol activates FTO demethylase to stabilize MAFG-AS1, suppressing hyperglycemia-induced vascular leakage and inflammation. Single-cell transcriptomics resolve FTO's paradoxical roles: Promoting pathological angiogenesis in endothelial cells while exerting antioxidant/anti-inflammatory effects via MAFG-AS1. A multidimensional epigenetic network integrates N6-methyladenosine, histone lactylation, and DNA methylation. Biomimetic nanoparticles enhance retinal targeting and bioavailability. The paradigm shifts from reactive treatment to AI-guided prevention, emphasizing early intervention via metabolic memory disruption and multi-tiered clinical strategies. These findings advance precision therapy by synergizing epigenetics, nanotechnology, and systems biology. |
| Publish Date |
2025-06-13 11:47 |
| Citation |
Luo C, Zheng ZG, Zeng MQ, Xu H, Yu XM, Sun D, He DJ. Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation. World J Diabetes 2025; 16(6): 107017 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i6/107017.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i6.107017 |
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