| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositis via Lactobacillus reuteri - dependent modulation of the gut microbiota
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Xue Lu, Zi-Xuan Wang, Xi-Min Liu, Hua Wu, Li-Jiang Ji and Jing Yan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Research Project of Higher Education Institutions in Jiangsu Province |
23KJB360013 |
| China and Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program |
MS2023001 |
| Guiding Project of Changshu Science and Technology Development Plan |
CSWS202411 |
|
| Corresponding Author |
Jing Yan, Adjunct Associate Professor, Key Laboratory for Metabolic Diseases in Chinese Medicine, The First Clinical Medical College, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. yanjing@njucm.edu.cn |
| Key Words |
Wumei Pills; Lactobacillus reuteri; Intestinal stem cells; Leucine-rich-repeat-containing G-protein-coupled receptor 5; Wingless-type/β-catenin pathway |
| Core Tip |
In this study, we established a 5-fluorouracil induced intestinal mucositis mouse model, and found that intestinal flora is an important mechanism causing chemotherapy-induced intestinal mucositis. Lactobacillus reuteri colonized in the intestinal mucosa and Wumei Pills ameliorated intestinal mucosa damage caused by 5-fluorouracil treatment, including improvement of body weight, pathological change, and proliferation level, reducement proinflammatory cytokine secretion (tumor necrosis factor-α, interleukin-6) and the lipopolysaccharides concentration. The repair process stimulated were also accompanied with increased leucine-rich-repeat-containing G-protein-coupled receptor 5 (+) and proliferating cell nuclear antigen. Furthermore, Wumei Pills and Lactobacillus reuteri activated the Wingless-type/β-catenin pathway to accelerate proliferation of intestinal epithelial, thus recovering damaged intestinal mucosa. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Lu DX, Wang ZX, Liu XM, Wu H, Ji LJ, Yan J. Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositis via Lactobacillus reuteri - dependent modulation of the gut microbiota. <i>World J Stem Cells</i> 2025; 17(9): 107025</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/107025.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.107025 |
