| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang-Yi Bu, Hao-Yuan Tan, An-Min Wang, Ming-Tong Wei, Sophie Pan, Juan-Zi Gao, Yong-Hai Li, Gui-Xiang Qian, Zi-Han Chen, Chao Ye and Wei-Dong Jia |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Wei-Dong Jia, MD, PhD, Professor, Department of Hepatic Surgery, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Science and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Luyang District, Hefei 230001, Anhui Province, China. jwd1968@ustc.edu.cn |
| Key Words |
Rotavirus infection; Paneth cells; Intestinal stem cells; Bone morphogenetic protein 7; Intestinal injury |
| Core Tip |
This study uncovers a novel regulatory role of Paneth cells in intestinal stem cell (ISC) homeostasis during rotavirus infection. While Paneth cells are known for supporting ISCs, we demonstrate that rotavirus directly infects Paneth cells, resulting in a loss of mature Paneth cells. Paneth-ISC communication is significantly enhanced post-infection, with upregulation of the bone morphogenic protein 7 (BMP7)-activin A receptor type 2B/BMP receptor type 1A-Smad pathway, which limits excessive ISC proliferation. These findings provide new insights into crypt homeostasis and suggest BMP7 signaling as a potential target for intestinal repair in viral infections. |
| Publish Date |
2025-07-11 07:47 |
| Citation |
<p>Bu XY, Tan HY, Wang AM, Wei MT, Pan S, Gao JZ, Li YH, Qian GX, Chen ZH, Ye C, Jia WD. Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury. <i>World J Gastroenterol</i> 2025; 31(26): 107044</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i26/107044.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i26.107044 |
