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Articles Published Processes
6/19/2025 8:18:35 AM | Browse: 23 | Download: 174
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Received |
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2025-03-14 06:45 |
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Peer-Review Started |
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2025-03-14 06:46 |
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To Make the First Decision |
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Return for Revision |
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2025-03-26 13:27 |
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Revised |
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2025-04-09 04:45 |
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Second Decision |
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2025-04-21 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-04-21 09:05 |
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Articles in Press |
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2025-04-21 09:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-06-10 07:01 |
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Publish the Manuscript Online |
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2025-06-19 08:18 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yasir Raza, Muhammed Mubarak, Muhammad Yousuf Memon and Mohammed Saud Alsulaimi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammed Mubarak, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com |
| Key Words |
Helicobacter pylori; Molecular pathogenesis; Gastric cancer; DNA repair; mutations |
| Core Tip |
Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer (GC), the third leading cause of cancer-related deaths. H. pylori triggers chronic inflammation, progressing through precancerous stages (gastritis, atrophy, intestinal metaplasia, dysplasia) to GC. Virulence factors like cytotoxin-associated gene A and vacuolating cytotoxin A activate oncogenic signaling pathways (PI3K/Akt, JAK/STAT, Ras/Raf/ERK), promoting uncontrolled cell proliferation and impairing DNA repair, leading to carcinogenic mutations. While 1%-3% of infected individuals develop GC, understanding these molecular mechanisms is crucial for identifying diagnostic markers and developing targeted therapies. This review explores H. pylori's role in gastric carcinogenesis, emphasizing bacterial-host interactions and potential preventive strategies. |
| Publish Date |
2025-06-19 08:18 |
| Citation |
<p>Raza Y, Mubarak M, Memon MY, Alsulaimi MS. Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer. <i>World J Gastrointest Pathophysiol</i> 2025; 16(2): 107052</p> |
| URL |
https://www.wjgnet.com/2150-5330/full/v16/i2/107052.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v16.i2.107052 |
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