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6/19/2025 8:18:35 AM | Browse: 12 | Download: 38
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 107052
Country Pakistan
Received
2025-03-14 06:45
Peer-Review Started
2025-03-14 06:46
To Make the First Decision
Return for Revision
2025-03-26 13:27
Revised
2025-04-09 04:45
Second Decision
2025-04-21 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-04-21 09:05
Articles in Press
2025-04-21 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-06-10 07:01
Publish the Manuscript Online
2025-06-19 08:18
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer
Manuscript Source Invited Manuscript
All Author List Yasir Raza, Muhammed Mubarak, Muhammad Yousuf Memon and Mohammed Saud Alsulaimi
ORCID
Author(s) ORCID Number
Yasir Raza http://orcid.org/0000-0003-0643-4398
Muhammed Mubarak http://orcid.org/0000-0001-6120-5884
Muhammad Yousuf Memon http://orcid.org/0009-0006-3632-616X
Mohammed Saud Alsulaimi http://orcid.org/0009-0008-3411-4459
Funding Agency and Grant Number
Corresponding Author Muhammed Mubarak, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Key Words Helicobacter pylori; Molecular pathogenesis; Gastric cancer; DNA repair; mutations
Core Tip Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer (GC), the third leading cause of cancer-related deaths. H. pylori triggers chronic inflammation, progressing through precancerous stages (gastritis, atrophy, intestinal metaplasia, dysplasia) to GC. Virulence factors like cytotoxin-associated gene A and vacuolating cytotoxin A activate oncogenic signaling pathways (PI3K/Akt, JAK/STAT, Ras/Raf/ERK), promoting uncontrolled cell proliferation and impairing DNA repair, leading to carcinogenic mutations. While 1%-3% of infected individuals develop GC, understanding these molecular mechanisms is crucial for identifying diagnostic markers and developing targeted therapies. This review explores H. pylori's role in gastric carcinogenesis, emphasizing bacterial-host interactions and potential preventive strategies.
Publish Date 2025-06-19 08:18
Citation <p>Raza Y, Mubarak M, Memon MY, Alsulaimi MS. Update on molecular pathogenesis of Helicobacter pylori-induced gastric cancer. <i>World J Gastrointest Pathophysiol</i> 2025; 16(2): 107052</p>
URL https://www.wjgnet.com/2150-5330/full/v16/i2/107052.htm
DOI https://dx.doi.org/10.4291/wjgp.v16.i2.107052
Full Article (PDF) WJGP-16-107052-with-cover.pdf
Manuscript File 107052_Auto_Edited_073558.docx
Answering Reviewers 107052-answering-reviewers.pdf
Audio Core Tip 107052-audio.opus
Conflict-of-Interest Disclosure Form 107052-conflict-of-interest-statement.pdf
Copyright License Agreement 107052-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 107052-non-native-speakers.pdf
Supplementary Material 107052-supplementary-material.pdf
Peer-review Report 107052-peer-reviews.pdf
Scientific Editor Work List 107052-scientific-editor-work-list.pdf
CrossCheck Report 107052-crosscheck-report.pdf