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Articles Published Processes
8/5/2025 8:25:46 AM | Browse: 5 | Download: 31
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Received |
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2025-03-18 12:30 |
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Peer-Review Started |
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2025-03-18 12:30 |
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To Make the First Decision |
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Return for Revision |
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2025-04-08 07:17 |
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Revised |
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2025-04-29 02:22 |
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Second Decision |
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2025-06-30 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-30 07:04 |
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Articles in Press |
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2025-06-30 07:04 |
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Publication Fee Transferred |
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2025-05-09 09:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-25 01:11 |
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Publish the Manuscript Online |
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2025-08-05 08:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tetrahydroxylated bile acids prevents malignant progression of Barret esophagus in vitro by inhibiting the interleukin-1β-nuclear factor kappa-B pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anatolii Mamchur, Shane Duggan, Hui Xue, Xiao-Jia Niu, Yu-Zhuo Wang, Zhen-Wei Ma, Dermot Kelleher, Victor Ling and Zu-Hua Gao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zu-Hua Gao, FRCPC, Full Professor, Head, Department of Pathology and Laboratory Medicine, University of British Columbia, G105-2211 Wesbrook Mall, Vancouver V6R2B5, British Columbia, Canada. zuhua.gao@ubc.ca |
| Key Words |
Pathway; Deoxycholic bile acid; Tetrahydroxylated bile acids; Histology; Cell viability; Mucin; Metaplasia; Inflammation; Barrett esophagus |
| Core Tip |
Barrett’s esophagus is a pathological precancerous condition. Hydrophobic bile acids could stimulate processes of malignant transition of Barrett esophagus tissue via activation proinflammatory signaling pathways. This study demonstrated that hydrophilic tetrahydroxylated bile acid could inhibit the cytotoxic and proinflammatory action of hydrophobic deoxycholic acid in adult stem cells isolated from Barrett esophagus. Co-treatment with hydrophilic tetrahydroxylated bile acids maintained the metaplastic intestinal-type cells in their differentiated state with preserved histology and mucin production. Thus, tetrahydroxylated bile acids have a potential protective role against the malignant progression of Barrett esophagus. |
| Publish Date |
2025-08-05 08:25 |
| Citation |
<p>Mamchur A, Duggan S, Xue H, Niu XJ, Wang YZ, Ma ZW, Kelleher D, Ling V, Gao ZH. Tetrahydroxylated bile acids prevents malignant progression of Barret esophagus in vitro by inhibiting the interleukin-1β-nuclear factor kappa-B pathway. <i>World J Gastroenterol</i> 2025; 31(29): 107066</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i29/107066.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i29.107066 |
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