BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/21/2025 5:29:08 AM | Browse: 41 | Download: 34
 |
Received |
|
2025-03-16 09:30 |
|
Peer-Review Started |
|
2025-03-17 00:48 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-04-17 10:56 |
|
Revised |
|
2025-05-16 13:24 |
|
Second Decision |
|
2025-06-30 02:21 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-07-02 00:44 |
|
Articles in Press |
|
2025-07-02 00:44 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2025-07-04 18:27 |
|
Typeset the Manuscript |
|
2025-08-11 07:13 |
|
Publish the Manuscript Online |
|
2025-08-21 05:29 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Entering the era of living biopharmaceuticals for treating knee osteoarthritis: A systematic review and network meta-analysis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Moaz Safwan, Mariam Safwan Bourgleh, Lubabah Baroudi, Aseel Almsned, Rawan AlBalawi, Batoul Aibour, Shahad AlFawaz, Safwan M Bourgleh and Khawaja Husnain Haider |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. khhaider@gmail.com |
| Key Words |
Biopharmaceuticals; Knee osteoarthritis; Living biodrugs; Mesenchymal stem cells; Meta-analysis; Network; Stem cells |
| Core Tip |
Knee osteoarthritis (KOA) is the leading cause of arthritis-related morbidity. Mesenchymal stem cells (MSCs) are emerging as living biodrugs, offering a potential treatment option due to their anti-inflammatory and immunomodulatory properties. They are available from different tissue sources, and we compare the safety and efficacy of allogenic MSCs vs autologous MSCs in treating KOA in clinical settings, using published data from 19 randomized controlled trials that report visual analog scale scores, Western Ontario and McMaster Universities Osteoarthritis scores, and adverse events. Our network meta-analysis data reveal that allogenic MSCs may offer superior clinical outcomes at a lower risk of adverse events than autologous MSCs in treating KOA. |
| Publish Date |
2025-08-21 05:29 |
| Citation |
<p>Safwan M, Bourgleh MS, Baroudi L, Almsned A, AlBalawi R, Aibour B, AlFawaz S, Bourgleh SM, Haider KH. Entering the era of living biopharmaceuticals for treating knee osteoarthritis: A systematic review and network meta-analysis. <i>World J Stem Cells</i> 2025; 17(8): 107076</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i8/107076.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i8.107076 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
