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Articles Published Processes
8/8/2025 9:09:12 AM | Browse: 20 | Download: 87
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Received |
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2025-03-16 09:44 |
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Peer-Review Started |
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2025-03-16 09:44 |
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To Make the First Decision |
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Return for Revision |
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2025-04-24 01:57 |
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Revised |
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2025-05-05 18:02 |
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Second Decision |
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2025-07-23 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-23 10:10 |
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Articles in Press |
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2025-07-23 10:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 04:06 |
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Publish the Manuscript Online |
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2025-08-08 09:09 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Rethinking the role of bisphosphonates after denosumab treatment in locally advanced or unresectable aneurysmal bone cysts: A meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gennady N Machak, Øyvind S Bruland, Alexey V Kovalev and Svetlana S Rodionova |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gennady N Machak, MD, PhD, Clinical and Diagnostic Center, FSBI "National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov" of the Ministry of Health of the Russian Federation, Moscow, Russia, 10, Priorova Street, Moscow 217299, Russia. machak.gennady@mail.ru |
| Key Words |
Aneurysmal bone cyst; Locally advanced/inoperable; Denosumab; Rebound hypercalcemia; Bisphosphonates |
| Core Tip |
Benign bone tumors containing giant cells undergo significant ossification after denosumab treatment. In these conditions, sequentially administered bisphosphonates (BPs) accumulate better in newly formed bone, which may lead to long-term local control, presumably due to a pro-apoptotic effect on residual tumor cells. In this context, we studied a group of patients with inoperable aneurysmal bone cysts (ABCs) who were treated with denosumab and found that among those patients who received BPs for post-denosumab rebound hypercalcemia, there were no local relapses. We assume that BPs could have the same irreversible effect on residual tumor cells in ABC and propose to continue experimental and prospective clinical studies to confirm this hypothesis. |
| Publish Date |
2025-08-08 09:09 |
| Citation |
<p>Machak GN, Bruland ØS, Kovalev AV, Rodionova SS. Rethinking the role of bisphosphonates after denosumab treatment in locally advanced or unresectable aneurysmal bone cysts: A meta-analysis. <i>World J Orthop</i> 2025; 16(8): 107083</p> |
| URL |
https://www.wjgnet.com/2218-5836/full/v16/i8/107083.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i8.107083 |
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