Publication Name	World Journal of Stem Cells
Manuscript ID	107124
Country	China

Received	2025-03-25 04:56
Peer-Review Started	2025-03-25 04:57
To Make the First Decision
Return for Revision	2025-04-28 09:15
Revised	2025-05-11 14:09
Second Decision	2025-06-27 06:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-04 10:23
Articles in Press	2025-07-04 10:23
Publication Fee Transferred	2025-05-13 13:37
Edit the Manuscript by Language Editor	2025-07-10 02:51
Typeset the Manuscript	2025-08-13 02:46
Publish the Manuscript Online	2025-08-21 05:29

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Wei Yang, Ya-Qiang Zhang, Hong Chang, Rui Gao, Dan Chen and Hao Yao
ORCID	Author(s) ORCID Number Cheng-Wei Yang http://orcid.org/0000-0001-6130-4874 Hao Yao http://orcid.org/0000-0002-2942-0004
Funding Agency and Grant Number	Funding Agency Grant Number Sichuan Province Science and Technology Support Program 2024NSFSC1292 Program of General Hospital of Western Theater Command 2021-XZYG-C45, 2021-XZYG-B32 Natural Science Foundation of Gansu Province 23JRRA538 National Natural Science Foundation of China 81601905
Corresponding Author	Hao Yao, PhD, Department of Hematology, The General Hospital of Western Theater Command PLA, No. 270 Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan Province, China. yaohao9001@163.com
Key Words	Tendon tissue engineering; Bone marrow-derived mesenchymal stem cells; Nanofiber scaffold; Cyclic tensile strain; Tenogenic differentiation; Ras homolog gene family (Rho)-associated coiled coil-containing kinase inhibition; Y27632
Core Tip	This study investigated the role of aligned nanofiber scaffolds and cyclic stretch in promoting Bone marrow-derived mesenchymal stem cell (BMSC) differentiation towards ligamentous tissue. We demonstrate that cyclic tensile strain, when applied to BMSCs on aligned nanofiber scaffolds, enhances tenogenic differentiation, as demonstrated by increased expression of collagen and tenogenic markers. These findings suggest that mechanical cues and scaffold alignment are critical in guiding BMSC differentiation for ligament tissue engineering, providing valuable insights for developing strategies to improve ligament regeneration.
Publish Date	2025-08-21 05:29
Citation	<p>Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. <i>World J Stem Cells</i> 2025; 17(8): 107124</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i8/107124.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i8.107124

Full Article (PDF)	WJSC-17-107124-with-cover.pdf
The ARRIVE Guidelines	107124-The-ARRIVE-Guidelines.pdf
Manuscript File	107124_Auto_Edited_023048.docx
Answering Reviewers	107124-answering-reviewers.pdf
Audio Core Tip	107124-audio.m4a
Biostatistics Review Certificate	107124-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107124-conflict-of-interest-statement.pdf
Copyright License Agreement	107124-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	107124-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	107124-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	107124-non-native-speakers.pdf
Supplementary Material	107124-supplementary-material.pdf
Peer-review Report	107124-peer-reviews.pdf
Scientific Misconduct Check	107124-scientific-misconduct-check.png
Scientific Editor Work List	107124-scientific-editor-work-list.pdf
CrossCheck Report	107124-crosscheck-report.pdf