Publication Name	World Journal of Hepatology
Manuscript ID	107160
Country	Sweden

Received	2025-03-17 03:48
Peer-Review Started	2025-03-17 08:41
To Make the First Decision
Return for Revision	2025-03-28 09:50
Revised	2025-04-08 20:58
Second Decision	2025-05-27 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-27 10:35
Articles in Press	2025-05-27 10:35
Publication Fee Transferred	2025-04-22 07:27
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-06-16 08:21
Publish the Manuscript Online	2025-06-26 07:27

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up
Manuscript Source	Unsolicited Manuscript
All Author List	Andreas Schult, Kirsten Mehlig, Kurt Svärdsudd, Sven Wallerstedt, Cecilia Björkelund, Per-Olof Hansson, Henrik Zetterberg and Jerzy Kaczynski
ORCID	Author(s) ORCID Number Andreas Schult http://orcid.org/0000-0002-2082-8724 Kirsten Mehlig http://orcid.org/0000-0002-2653-0734 Kurt Svärdsudd http://orcid.org/0000-0002-8925-9670 Cecilia Björkelund http://orcid.org/0000-0003-4083-7342 Per-Olof Hansson http://orcid.org/0000-0001-6323-0506 Henrik Zetterberg http://orcid.org/0000-0003-3930-4354 Jerzy Kaczynski http://orcid.org/0009-0000-2884-4975
Funding Agency and Grant Number
Corresponding Author	Andreas Schult, MD, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 3, Gothenburg 41390, Västra Götaland, Sweden. andreas.schult@vgregion.se
Key Words	Insulin; Liver function tests; Alcohol; Metabolic dysfunction associated steatotic liver disease; Liver cirrhosis
Core Tip	Insulin resistance is a cardiometabolic risk factor. There is a paucity of cohort studies examining the effect of insulin on liver function tests and liver disease. This cohort study followed 2085 participants for up to 24 years. High insulin levels were associated to elevated liver enzymes and clinical manifest liver disease.
Publish Date	2025-06-26 07:27
Citation	<p>Schult A, Mehlig K, Svärdsudd K, Wallerstedt S, Björkelund C, Hansson PO, Zetterberg H, Kaczynski J. Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up. <i>World J Hepatol</i> 2025; 17(6): 107160</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i6/107160.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i6.107160

Full Article (PDF)	WJH-17-107160-with-cover.pdf
STROBE Statement	107160-STROBE-statement.pdf
Manuscript File	107160_Auto_Edited_035112.docx
Answering Reviewers	107160-answering-reviewers.pdf
Audio Core Tip	107160-audio.mp3
Biostatistics Review Certificate	107160-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	107160-conflict-of-interest-statement.pdf
Copyright License Agreement	107160-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	107160-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	107160-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	107160-non-native-speakers.pdf
Supplementary Material	107160-supplementary-material.pdf
Peer-review Report	107160-peer-reviews.pdf
Scientific Misconduct Check	107160-scientific-misconduct-check.png
Scientific Editor Work List	107160-scientific-editor-work-list.pdf
CrossCheck Report	107160-crosscheck-report.pdf