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Articles Published Processes
7/24/2025 9:11:32 AM | Browse: 14 | Download: 45
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Received |
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2025-03-18 13:46 |
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Peer-Review Started |
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2025-03-21 00:09 |
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To Make the First Decision |
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Return for Revision |
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2025-04-01 12:41 |
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Revised |
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2025-04-03 12:25 |
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Second Decision |
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2025-06-03 03:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-04 08:51 |
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Articles in Press |
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2025-06-04 08:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-06-19 22:25 |
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Typeset the Manuscript |
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2025-07-15 13:10 |
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Publish the Manuscript Online |
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2025-07-24 09:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fatma Sengul Bag and Omer Faruk Bag |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fatma Sengul Bag, Assistant Professor, PhD, Department of Biochemistry, Adıyaman University Faculty of Pharmacy, Central Classroom C Block, 3 Floor, Adıyaman 02040, Türkiye. fatmasengul245@gmail.com |
| Key Words |
Mesenchymal stem cells; Exosomes; Autoimmune diseases; Immunomodulation; Behçet’s disease; Systemic lupus erythematosus; Rheumatoid arthritis; Multiple sclerosis |
| Core Tip |
Autoimmune diseases result from dysregulated immune responses directed against self-antigens, leading to chronic inflammation and tissue damage. Mesenchymal stem cells (MSCs) and MSC-derived exosomes have demonstrated significant potential as therapeutic agents due to their strong immunomodulatory and regenerative properties. MSC-derived exosomes modulate immune responses by regulating cytokine secretion, suppressing inflammatory cell activity, and promoting immune tolerance. Their advantages - including low immunogenicity and the ability to cross biological barriers - make them a promising cell-free therapy for autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and Behçet’s disease. For all encouraging preclinical and clinical findings, further research is required to standardize protocols, optimize therapeutic efficacy, and ensure long-term safety. |
| Publish Date |
2025-07-24 09:11 |
| Citation |
<p>Sengul Bag F, Bag OF. Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases. <i>World J Stem Cells</i> 2025; 17(7): 107202</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i7/107202.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i7.107202 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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