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2/10/2026 10:35:36 AM | Browse: 5 | Download: 38
Publication Name World Journal of Methodology
Manuscript ID 107203
Country India
Received
2025-03-19 02:02
Peer-Review Started
2025-03-27 09:20
First Decision by Editorial Office Director
2025-05-12 03:49
Return for Revision
2025-05-12 03:49
Revised
2025-05-15 13:56
Publication Fee Transferred
Second Decision by Editor
2025-08-15 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-08-15 06:38
Articles in Press
2025-08-15 06:38
Edit the Manuscript by Language Editor
2025-08-21 20:25
Typeset the Manuscript
2026-01-26 07:56
Publish the Manuscript Online
2026-02-10 10:35
ISSN 2222-0682 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rehabilitation
Manuscript Type Observational Study
Article Title Comparative effectiveness of amitriptyline vs duloxetine in the treatment of chronic low back pain: An observational study
Manuscript Source Invited Manuscript
All Author List Nityananda Sardar, Raktim Swarnakar, Soumyadipta Ghosh and Pankaj Kumar Mandal
ORCID
Author(s) ORCID Number
Nityananda Sardar http://orcid.org/0009-0002-0330-6059
Raktim Swarnakar http://orcid.org/0000-0002-7221-2825
Soumyadipta Ghosh http://orcid.org/0009-0000-2128-3394
Funding Agency and Grant Number
Corresponding Author Raktim Swarnakar, Assistant Professor, MD, Faculty of Physical Medicine and Rehabilitation, National Cancer Insitute, Jhajjar Campus, All India Institute of Medical Sciences (AIIMS), New Delhi, New Delhi 110029, Delhi, India. raktimswarnakar@hotmail.com
Key Words Amitriptyline; Duloxetine; Chronic low back pain; Neuropathic pain; Pain
Core Tip This study compared the efficacy and safety of Amitriptyline and Duloxetine in treating chronic low back pain (CLBP). Both medications were effective in reducing pain, as evidenced by statistically significant improvements in the visual analog scale at 1, 4, and 12 weeks. However, Duloxetine demonstrated a more favorable side effect profile and better long-term sustained effects compared to Amitriptyline, with fewer anticholinergic and sedative effects. These findings suggest that while both drugs are viable options for CLBP management, Duloxetine may be preferred for patients seeking a treatment with fewer side effects. The choice of medication should be individualized based on patient-specific factors and health conditions.
Publish Date 2026-02-10 10:35
Citation

Sardar N, Swarnakar R, Ghosh S, Mandal PK. Comparative effectiveness of amitriptyline vs duloxetine in the treatment of chronic low back pain: An observational study. World J Methodol 2026; 16(1): 107203

URL https://www.wjgnet.com/2222-0682/full/v16/i1/107203.htm
DOI https://dx.doi.org/10.5662/wjm.v16.i1.107203
Full Article (PDF) WJM-16-107203-with-cover.pdf
STROBE Statement 107203-STROBE-statement.pdf
Manuscript File 107203_Auto_Edited_035454.docx
Answering Reviewers 107203-answering-reviewers.pdf
Audio Core Tip 107203-audio.mp3
Biostatistics Review Certificate 107203-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 107203-conflict-of-interest-statement.pdf
Copyright License Agreement 107203-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 107203-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 107203-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 107203-non-native-speakers.pdf
Peer-review Report 107203-peer-reviews.pdf
Scientific Misconduct Check 107203-scientific-misconduct-check.png
Scientific Editor Work List 107203-scientific-editor-work-list.pdf
CrossCheck Report 107203-crosscheck-report.pdf