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Articles Published Processes
7/14/2025 12:55:53 PM | Browse: 7 | Download: 28
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Received |
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2025-03-19 13:02 |
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Peer-Review Started |
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2025-03-19 13:02 |
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To Make the First Decision |
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Return for Revision |
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2025-04-09 01:50 |
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Revised |
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2025-04-20 08:08 |
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Second Decision |
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2025-05-22 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-05-22 06:48 |
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Articles in Press |
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2025-05-22 06:48 |
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Publication Fee Transferred |
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2025-04-22 08:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-02 03:47 |
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Publish the Manuscript Online |
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2025-07-14 12:55 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Stemness signatures reflect prognostic disturbances in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Feng Pu, Xiao Yang, Xiao-Qing Wang, Xiao-Guang Guo and Mi-Yuan Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Feng Pu, Department of Gastroenterology, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, No. 97 Renmin South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. 1047951869@qq.com |
| Key Words |
Gastric cancer; Gastric cancer stemness sensitive; Cancer stem cells; Gastric cancer stem cells; Niemann-Pick protein C2 |
| Core Tip |
The results of this study indicate that the proposed gastric cancer (GC) stemness sensitivity model offers prognostic value that exceeds that of conventional clinicopathological staging, therefore providing more precise guidance for clinical decision-making and post-treatment management. The strong positive association between Niemann-Pick type C2 (NPC2) expression and GC progression highlights NPC2 as a promising prognostic biomarker. However, the functional role of NPC2 in GC remains insufficiently characterized. In this study, cellular experiments demonstrated that elevated expression of NPC2 enhances tumor cell stemness, invasiveness, migratory capacity, and resistance to radiotherapy and standard chemotherapeutic agents. |
| Publish Date |
2025-07-14 12:55 |
| Citation |
<p>Pu WF, Yang X, Wang XQ, Guo XG, Yang MY. Stemness signatures reflect prognostic disturbances in gastric cancer. <i>World J Gastrointest Oncol</i> 2025; 17(7): 107211</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i7/107211.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i7.107211 |
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